Plasma lipid profile and lipid peroxidation in overweight or obese children and adolescents

Lima, Severina Carla Vieira Cunha; Arrais, Ricardo Fernando; Almeida, M. Gabriela; Souza, Zélia M; Pedrosa, Lúcia Fátima Campos

doi:10.2223/jped.1129

Cited by 28 publications

(16 citation statements)

References 18 publications

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“…Similar results were described, in which adolescents with high BMI also had elevated TC and TG and low HDL-C concentrations (30)(31)(32). Cardiovascular heart diseases have different risk factors, and lipid profile is probably the most investigated of them.…”

Section: Discussionsupporting

confidence: 80%

Is Plasma Alpha-Tocopherol Associated with Electronegative LDL in Obese Adolescents?

Silva

Mello

Sanches

et al. 2013

J Nutr Sci Vitaminol

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Summary Obesity has increased in children and adolescents. What is reflected in the early occurrence of cardiometabolic alterations, like hypertension and type 2 diabetes, where the oxLDL formation is stimulated. Various studies have shown that plasma a-tocopherol (a-TP) can protect LDL against oxidation. Nevertheless, the action of plasma a-TP in cardiovascular diseases remains controversial. We conducted a cross-sectional study to evaluate plasma a-TP and its impact on the concentration of LDL(2). Adolescents (n5150) of both sexes were classified into three groups: healthy weight (HW; 50%), overweight (OV; 22%), and obese (OB; 28%). Lipid profile, LDL(2), anti-oxLDL and anti-LDL(2) antibodies, CRP (ELISA) and plasma a-TP (HPLC) were analyzed. Demographic, anthropometric, and food intake data were evaluated. Crude and energy-adjusted intake of vitamin E in the OB group were higher than in the HW group (p,0.001). Crude and energy-adjusted vitamin E intakes were not correlated with plasma a-TP (r520.07; p50. 412 and r520.064; p50.467, respectively). Subjects in the OB group had higher TC and LDL-C and lower HDL-C than in the HW and OV groups. C-reactive protein and anti-oxLDL antibodies changed as a function of BMI. The impact of obesity was reinforced by high values for LDL(2) and low content of plasma a-TP in comparison with the HW (p,0.001) and OV groups (p50.03). This negative profile was maintained for the ratio between a-TP and TC or LDL-C. Plasma a-TP, a-TP/TC and a-TP/LDL-C were negatively associated with LDL(2) and other cardiometabolic risk factors (BMI, WC, AC and anti-oxLDL). Our results demonstrate that obesity in adolescents is associated with high levels of LDL(2) and low plasma a-TP content.

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Section: Discussionsupporting

confidence: 80%

Is Plasma Alpha-Tocopherol Associated with Electronegative LDL in Obese Adolescents?

Silva

Mello

Sanches

et al. 2013

J Nutr Sci Vitaminol

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“…13 Studies also show that HDL-C have a protective role in the development of atherogenesis 19,20 ; and the increase of its levels would be directly associated with reduced cardiovascular risk. 21,22 In this present study, the behavior was regularly among the different age groups, but was observed between the sexes, significantly higher levels in females, which may explain the lower prevalence of vascular events (CVD and/or stroke) in all ranges age in females compared to males. It is also observed that the presence of high levels of triglycerides associated with low HDL-C, predisposes to the development of acute myocardial infarction during life, in spite of individuals with high levels of triglycerides do not have higher levels of coronary events in relation to population in common.…”

Section: Discussionmentioning

confidence: 44%

A Decade of Lipid Profiles: A Gender Focus

Leão¹,

Carvalho²,

Galvão³

et al. 2016

Heart Res Open J

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Introduction and Objectives:The lipid profile is an important predictor of the risk of coronary heart disease (CHD). Higher rates of total cholesterol (TC) and cholesterol of low-density lipoprotein (LDL-C) increase the chances of developing this disease. However, it is known that women due to hormonal factors would have fewer cardiovascular events. The main objective of this article is to assess the association among different parameters of the lipid profile between the different sexes in the population of a city in Brazil. Methods: This is a descriptive, longitudinal and retrospective study based on secondary data collected in the period from 2003 to 2013 in a medical laboratory in Aracaju, Brazil. The lipid profile was determined using the following markers: total cholesterol (TC); high-density lipoprotein cholesterol (HDL-C); low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG). Statistical analysis was performed using measures of central tendency and variance. The inferential analysis was performed by student's t test and the p-value was 0.05. Results: The sample consists of 63,396 people, 24,425 male and 38,971 female, with mean age of 42.02±17.38 years. The mean value of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride was respectively, 193.39±43.62 mg/dl, 48.80±11.24 mg/dl, 118.35±36.75 mg/dl and 131.28±82.21 mg/dl. Between the genres, it was observed statistical significant differences between all parameters of lipid profile (p<0.0001). Conclusion: We concluded that women have higher rates of total cholesterol and low-density lipoprotein cholesterol; while men have lower rates of high-density lipoprotein cholesterol and higher of triglyceride, which predisposes males to the development of metabolic syndrome.

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“…The LDL phenotype B, being smaller and denser, more easily cross the endothelial barrier and are more easily oxidable, which also makes them more atherogenic 27 . Thus, even in individuals with normal LDL-c levels, the lipid profile can be less favorable, given the proportion between the lipoprotein subclasses 28 .…”

Section: Discussionmentioning

confidence: 99%

Perfil lipídico em escolares de Recife - PE

Pereira¹,

Arruda²,

Cavalcanti³

et al. 2010

Arq. Bras. Cardiol.

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Plasma lipid profile and lipid peroxidation in overweight or obese children and adolescents

Abstract: In the present population, the greatest alterations in lipid profile were observed in obese and overweight males. Plasma lipid peroxidation was more evident in obese males and females.

Cited by 28 publications

References 18 publications

Is Plasma Alpha-Tocopherol Associated with Electronegative LDL in Obese Adolescents?

Is Plasma Alpha-Tocopherol Associated with Electronegative LDL in Obese Adolescents?

A Decade of Lipid Profiles: A Gender Focus

Perfil lipídico em escolares de Recife - PE

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