SUMMARY Two hundred men with normal ECGs at rest had maximum treadmill tests using 14 The diagnostic impact of maximal treadmill testing using 14 ECG leads is greatest in men with typical and probable angina. In these two clinical subsets the presence or absence of horizontal or downsloping ST-segment depression 1 mm, ST-segment elevation > 1 mm, or a slowly upsloping ST-segment depression > 2 mm at 0.08 seconds after the J point in any of 14 leads is highly predictive of multivessel disease when used in conjunction with treadmill work time. The predictive value of maximal treadmill testing using 14 ECG leads in men with nonspecific chest pain is less useful. The lower predictive value of a positive test occurs because this clinical subset has less severe coronary disease and a lower prevalence of disease than men with anginal symptoms. Recording a single lead such as CM, would suffice for the majority of patients in this subset using either horizontal or downsloping ST-segment depression 2 1 mm or ST-segment elevation > 1 mm as criteria for positivity.THE SENSITIVITY AND EFFICIENCY of maximal treadmill testing in men with angina pectoris can be increased by recording multiple ECG leads and combining the results with physiological data collected during exercise." 2 Little information is available on multiple-lead exercise testing in subsets of patients with a lower disease prevalence, such as asymptomatic patients, those with nonspecific chest pain, and women. Several investigators have reported decreased specificity of exercise test results in selected populations with a low disease prevalence.3-5 There is concern that the use of multiple ECG leads could increase the false positive rate in this type of population.