Exercise-Induced Oxidative Stress

Vollaard, Niels; Shearman, Jeremy P.; Cooper, Chris E.

doi:10.2165/00007256-200535120-00004

Cited by 255 publications

(86 citation statements)

References 176 publications

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“…Excessive levels of ROS may alter the muscle, mainly through inflammatory processes (28). Levels of DCF-RS were increased in the SEP group; however, the SEP+CWI group did not present an increment, which demonstrated that CWI may prevent the DCF-RS increase caused in our protocol of exercise-induced exhaustion.…”

Section: Discussionmentioning

confidence: 99%

Cryotherapy: biochemical alterations involved in reduction of damage induced by exhaustive exercise

Furtado

Hartmann

Martins

et al. 2018

Braz J Med Biol Res

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When exercises are done in intense or exhaustive modes, several acute biochemical mechanisms are triggered. The use of cryotherapy as cold-water immersion is largely used to accelerate the process of muscular recovery based on its anti-inflammatory and analgesic properties. The present study aimed to study the biochemical effects of cold-water immersion treatment in mice submitted to exercise-induced exhaustion. Swiss albino mice were divided into 4 treatment groups: control, cold-water immersion (CWI), swimming exhaustive protocol (SEP), and SEP+CWI. Treatment groups were subdivided into times of analysis: 0, 1, 3, and 5 days. Exhaustion groups were submitted to one SEP session, and the CWI groups submitted to one immersion session (12 min at 12°C) every 24 h. Reactive species production, inflammatory, cell viability, and antioxidant status were assessed. The SEP+CWI group showed a decrease in inflammatory damage biomarkers, and reactive species production, and presented increased cell viability compared to the SEP group. Furthermore, CWI increased acetylcholinesterase activity in the first two sessions. The present study showed that CWI was an effective treatment after exercise-induced muscle damage. It enhanced anti-inflammatory response, decreased reactive species production, increased cell viability, and promoted redox balance, which could decrease the time for the recovery process.

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Section: Discussionmentioning

confidence: 99%

Cryotherapy: biochemical alterations involved in reduction of damage induced by exhaustive exercise

Furtado

Hartmann

Martins

et al. 2018

Braz J Med Biol Res

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“…Furthermore the current study employed eccentric exercise and may highlight a differential oxidative response to fish oils with varying modes of exercise. Indeed it is likely that the mechanisms through which reactive oxygen species are generated will depend upon the mode of exercise employed (Vollaard et al, 2005) and so any modulation of these mechanisms (e.g., via fish oil-derived n-3 PUFAs) will be dependent upon the exercise mode employed. However, as the precise mechanisms responsible for exercise-induced free radical production, under these various exercise modes, remains to be elucidated, uncovering the mechanisms underlying the findings of the current studies are problematic.…”

Section: Discussionmentioning

confidence: 99%

Fish Oil Supplementation Reduces Markers of Oxidative Stress But Not Muscle Soreness After Eccentric Exercise

Gray¹,

Chappell²,

Jenkinson³

et al. 2014

International Journal of Sport Nutrition and Exercise Metabolism

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Due to the potential anti-inflammatory properties of fish-derived long chain n-3 fatty acids, it has been suggested that athletes should regularly consume fish oils-although evidence in support of this recommendation is not clear. While fish oils can positively modulate immune function, it remains possible that, due to their high number of double bonds, there may be concurrent increases in lipid peroxidation. The current study aims to investigate the effect of fish oil supplementation on exercise-induced markers of oxidative stress and muscle damage. Twenty males underwent a 6-week double-blind randomized placebo-controlled supplementation trial involving two groups (fish oil or placebo). After supplementation, participants undertook 200 repetitions of eccentric knee contractions. Blood samples were taken presupplementation, postsupplementation, immediately, 24, 48, and 72 hr postexercise and muscle soreness/maximal voluntary contraction (MVC) assessed. There were no differences in creatine kinase, protein carbonyls, endogenous DNA damage, muscle soreness or MVC between groups. Plasma thiobarbituric acid reactive substances (TBARS) were lower (p < .05) at 48 and 72 hr post exercise and H2O2 stimulated DNA damage was lower (p < .05) immediately postexercise in the fish oil, compared with the control group. The current study demonstrates that fish oil supplementation reduces selected markers of oxidative stress after a single bout of eccentric exercise.

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“…Qualitative muscle changes might relate to the observed difference in muscle performance. Muscle contraction is influenced by a variety of factors, including muscle fiber type, pH, sarcoplasmic reticulum function, and energy supply, and the functions of proteins involved in these processes is affected by oxidative stress (Smith and Reid 2006;Vollaard et al 2005). The higher oxidative stress observed in SAMP1 controls is considered to be a cause of their accelerated senescence and aging-related alterations in cell function (Hosokawa 2002).…”

Section: Discussionmentioning

confidence: 99%

Suppression of the aging-associated decline in physical performance by a combination of resveratrol intake and habitual exercise in senescence-accelerated mice

et al. 2008

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The decline in physical performance with increasing age is a crucial problem in our aging society. We examined the effects of resveratrol, a natural polyphenolic compound present in grapes, in combination with habitual exercise on the aging-associated decline in physical performance in senescence-accelerated prone mice (SAMP1). The endurance capacity of SAMP1 mice undergoing an exercise regimen (SAMP1-Ex) decreased over 12 weeks whereas that of SAMP1 mice fed 0.2% (w/w) resveratrol along with exercise (SAMP1-ExRes) remained significantly higher. In the SAMP1-ExRes group, there was a significant increase in oxygen consumption and skeletal muscle mRNA levels of mitochondrial function-related enzymes. These results suggest that the intake of resveratrol, together with habitual exercise, is beneficial for suppressing the aging-related decline in physical performance and that these effects are attributable, at least in part, to improved mitochondrial function in skeletal muscle.

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Exercise-Induced Oxidative Stress

Cited by 255 publications

References 176 publications

Cryotherapy: biochemical alterations involved in reduction of damage induced by exhaustive exercise

Cryotherapy: biochemical alterations involved in reduction of damage induced by exhaustive exercise

Fish Oil Supplementation Reduces Markers of Oxidative Stress But Not Muscle Soreness After Eccentric Exercise

Suppression of the aging-associated decline in physical performance by a combination of resveratrol intake and habitual exercise in senescence-accelerated mice

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