Interaction of a Triruthenium ortho-Metallated Phenazine with Cytochrome P450 Enzymes
Luis Guilherme do Nascimento,
Maike Barbetta,
Otávio Chaves
et al.
Abstract:The triruthenium ortho-metallated phenazine [Ru3O(CH3COO)5(py)2(dppzCl)]PF6 (1, py = pyridine; dppz-Cl = 7-chlorodipyrido[3,2-a:2’,3’-c]phenazine) is a potential metallo-drug candidate with in vitro anticancer and trypanosomicidal activities. It also showed strong interactions with deoxyribonucleic acid (DNA) and human serum albumin due to the presence of the planar and π-conjugated phenazine in its structure. Pursuing our interest in compound 1 behavior in a biological environment, we described its interactio… Show more
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