QUANTIFICATION OF BERGENIN, ANTIOXIDANT ACTIVITY AND NITRIC OXIDE INHIBITION FROM BARK, LEAF AND TWIG OF Endopleura uchi

Muniz, Magno Perêa; Nunomura, Sergio Massayoshi; Lima, Émerson Silva; Lima, Arleilson S.; Almeida, Patrícia Danielle Oliveira de; Nunomura, Rita C. S.

doi:10.21577/0100-4042.20170514

Cited by 7 publications

(9 citation statements)

References 23 publications

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“…From 180.1 to 236 mg of bergenin were found in 100 g of yellow uxi pulp (dry weight). In comparison with other parts of the E. uchi plant, the highest content of bergenin was found in the bark (4,170 -4,750 mg 100 g -1 ), twigs (2,660 -3,440 mg 100 g -1 ), and leaves (2,230 -3,870 mg 100 g -1 ) (Muniz et al 2020). Several in vivo and in vitro studies have shown biological activities of bergenin, such as neuroprotective (Takahashi et al 2003), hepatoprotective (Popov et al 2005), anti-inflammatory (Nunomura et al 2009), and anti-arthritic (Nazir et al 2007).…”

Section: Discussionmentioning

confidence: 87%

“…In the region of Belém, in the eastern Brazilian Amazon, yellow uxi is used for its timber, and its oil, fruits, and trunk bark are used in traditional medicines to treat arthritis, cholesterol, and sinusitis (Herrero-Jáuregui et al 2009;Shanley et al 2012). The bark of yellow uxi is rich in bergenin, a 4-O-methyl gallic acid C-glycoside derivate, which shows anti-inflammatory, antifungal, hepatoprotective, and neuroprotective activities (Bastos et al 2020;Muniz et al 2020;Machado et al 2010;Nunomura et al 2009;Pontes et al 2009).…”

Section: Introductionmentioning

confidence: 99%

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Nutritional characterization, antioxidant activity and bergenin content of the pulp of Endopleura uchi

OLIVEIRA,

CASTRO,

NASCIMENTO

et al. 2023

Acta Amaz.

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The yellow uxi (Endopleura uchi) is a tree native to the Amazon and its fruits are appreciated in the region. It is rich in total phenols and its bark is known to have high bergenin content, an isocoumarin derivative that presents several pharmacological activities. Yet the nutritional and functional properties of the fruit are still little known. We analyzed the nutritional, centesimal, and mineral properties, and the antioxidant activity and total phenol content of the alcoholic extract of yellow uxi fruit pulp from different locations in the Amazon. The bergenin content was also quantified. Average pulp yield was 45.66 ± 4.44% (w/w), with 60.1 - 89.2 g 100 g-1 of moisture and 1.28 - 1.32 g 100 g-1 of ash (dry basis). Calcium (78.2 - 87.1 mg 100 g-1) and potassium (260.2 - 395 mg 100 g-1) were the most abundant minerals in the pulp. Aluminum concentration was high compared to other Amazonian fruits (23.7 - 28.7 mg 100 g-1). The high caloric value of the pulp (325.3 ± 20.9 Kcal 100 g-1) is attributed to its lipid (32 - 44.9%) and carbohydrate (48.2 - 64.1%) content. The scavenging activity of DPPH was 1.95 - 20.68%, which was highly associated with the total phenolic content (16.91 - 30.07 µg GAE mg-1). Bergenin content was 180.8 ± 55.3 mg 100 g-1. We conclude that E. uchi pulp has high caloric and mineral content, and it is also a source of bergenin, thus this fruit has a potential nutritional and functional value.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Nutritional characterization, antioxidant activity and bergenin content of the pulp of Endopleura uchi

OLIVEIRA,

CASTRO,

NASCIMENTO

et al. 2023

Acta Amaz.

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“…Besides antimicrobial activity, bergenin has also been pointed out as one of the main substances responsible for antimalarial [ 24 ], anti-inflammatory [ 48 , 49 ], antinociceptive [ 50 ], anxiolytic [ 51 ], and antioxidant activities [ 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Extracts from the Humiria balsamifera (Aubl)

Dias

Filho

Carneiro

et al. 2021

Plants

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Humiria balsamifera (Aubl), commonly known as “mirim”, is a plant of the Humiriaceae family, which consists of 39 species divided between eight genera: Duckesia, Endopleura, Humiria, Humiriastrum, Hylocara, Sacoglottis, Schistostemon, and Vantenea. This study aimed to characterize H. balsamifera extracts by LC-MS/MS and evaluate their antimicrobial potential through in vitro and in vivo assays. The leaves and stem bark of H. balsamifera were collected and dried at room temperature and then ground in a knife mill. The extracts were prepared with organic solvents in order to increase the polarity index (hexane, ethyl acetate, and methanol). The antimicrobial effects of these extracts were evaluated against the following bacterial strains: Escherichia coli ATCC 25922, Listeria monocytogenes ATCC 15313, Salmonella enterica Typhimurium ATCC 14028, and Staphylococcus aureus ATCC 6538. The best activity was observed in the ethyl acetate (EALE = 780 µg/mL), methanol (MLE = 780 µg/mL), and hexane (HLE = 1560 µg/mL) leaf extracts against S. aureus. Considering the results for both antimicrobial and antibiofilm activities, the EALE extract was chosen to proceed to the infection assays, which used Tenebrio molitor larvae. The EALE treatment was able to extend the average lifespan of the larvae (6.5 days) in comparison to S. aureus-infected larvae (1 day). Next, the samples were characterized by High-Performance Liquid Chromatography coupled to a mass spectrometer, allowing the identification of 11 substances, including seven flavonoids, substances whose antimicrobial activity is already well-reported in the literature. The number of bioactive compounds found in the chemical composition of H. balsamifera emphasizes its significance in both traditional medicine and scientific research that studies new treatments based on substances from the Brazilian flora.

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“…Drypetes tessmanniana, Putranjiva roxburghii, Uapaca ambanjensis, and Euphorbia tirucalli L. belonging to the family Euphorbiaceae; Salix tetrasperma and Populus davidiana belonging to the family Salicaceae; Terminalia avicennioides and Combretum duarteanum of the family Combretaceae; Luehea ochrophylla and Ancistrocarpus densispinosus of the family Tiliaceae; Prunus turfosa and Prunus lusitanica of the family Rosaceae and Maytenus ilicifolia and Maytenus aquifolium of family Celastraceae have been reported for the extraction of friedelin (Table 1). Salix tetrasperma Salicaceae 80% aqueous methanol [35] Calophyllum pinetorum Clusiaceae Sequentially with n-hexane and ethyl acetate [36] Drypetes tessmanniana Euphorbiaceae Methanol [37] Prunus turfosa Rosaceae 5% benzene in chloroform [38] Terminalia avicennioides Combretaceae Petroleum ether, ethyl acetate, chloroform, and methanol [40] Putranjiva roxburghii Euphorbiaceae Chloroform [41] Endopleura uchi Humiriaceae Hexane [42] Luehea ochrophylla Tiliaceae Hexane and ethanol [43] Ancistrocarpus densispinosus Oliv. Tiliaceae Methanol [44] Syzygium cumini L. Myrtaceae 70% methanol [45] Garcinia prainiana Clusiaceae n-hexane [27] Uapaca ambanjensis Euphorbiaceae Sequentially with n-hexane, dichloromethane, ethyl acetate, and methanol, respectively [46] Elaeocarpus floribundus Elaeocarpaceae Sequentially with hexane, chloroform, ethyl acetate, and methanol [47] Elytranthe parasitica Loranthaceae Methanol [48] Dombeya torrida Sterculiaceae Chloroform [49] Leaves Azima tetracantha Lam.…”

Section: Sources Of Friedelinmentioning

confidence: 99%

Friedelin: Structure, Biosynthesis, Extraction, and Its Potential Health Impact

Singh,

Shrivastava,

Mishra

et al. 2023

Molecules

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Pharmaceutical companies are investigating more source matrices for natural bioactive chemicals. Friedelin (friedelan-3-one) is a pentacyclic triterpene isolated from various plant species from different families as well as mosses and lichen. The fundamental compounds of these friedelane triterpenoids are abundantly found in cork tissues and leaf materials of diverse plant genera such as Celastraceae, Asteraceae, Fabaceae, and Myrtaceae. They possess many pharmacological effects, including anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. Friedelin also has an anti-insect effect and the ability to alter the soil microbial ecology, making it vital to agriculture. Ultrasound, microwave, supercritical fluid, ionic liquid, and acid hydrolysis extract friedelin with reduced environmental impact. Recently, the high demand for friedelin has led to the development of CRISPR/Cas9 technology and gene overexpression plasmids to produce friedelin using genetically engineered yeast. Friedelin with low cytotoxicity to normal cells can be the best phytochemical for the drug of choice. The review summarizes the structural interpretation, biosynthesis, physicochemical properties, quantification, and various forms of pharmacological significance.

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QUANTIFICATION OF BERGENIN, ANTIOXIDANT ACTIVITY AND NITRIC OXIDE INHIBITION FROM BARK, LEAF AND TWIG OF Endopleura uchi

Cited by 7 publications

References 23 publications

Nutritional characterization, antioxidant activity and bergenin content of the pulp of Endopleura uchi

Nutritional characterization, antioxidant activity and bergenin content of the pulp of Endopleura uchi

Antimicrobial Activity of Extracts from the Humiria balsamifera (Aubl)

Friedelin: Structure, Biosynthesis, Extraction, and Its Potential Health Impact

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