Transcatheter Aortic Valve Implantation in Bicuspid Aortic Valve with Aortic Stenosis: a Meta-Analysis and Trial Sequential Analysis

Procedural and clinical outcomes of transcatheter aortic valve replacement in bicuspid aortic valve patients: a systematic review and meta-analysis

“…Major bleeding (3.5%), major vascular complications (2.5%) and acute kidney injury (2.1%) were the next most common complications in this patient cohort. This is consistent with previously published systematic reviews, which reported a new PPI rate of 12.2-18.5%, a major bleeding rate of 4.2-20.0%, an acute kidney injury risk of 2.04-6.50%, and a major vascular complication rate of 1.3-8.5% (46,(48)(49)(50)(51)(52)(53)(54)(55)(56). Following sensitivity analysis, Pineda et al was excluded from meta-analysis of AKI due to its significantly high rate, which was not representative of the current patient cohort.…”

“…Device success rate (87.5%) reported in this study is comparable with previously published systematic reviews, which range from 85.8% to 95.2% (46)(47)(48)(49). Post-procedural mean aortic gradient (11.2 mmHg) was also comparable with previously published gradients, which range from 6.0 to 16.0 mmHg (49,50). The rate of moderate to severe PVL (3.7%) was found to be lower in this cohort compared to previously published cohorts, which range from 8.8% to 12.2% (46)(47)(48)50).…”

“…Post-procedural mean aortic gradient (11.2 mmHg) was also comparable with previously published gradients, which range from 6.0 to 16.0 mmHg ( 49 , 50 ). The rate of moderate to severe PVL (3.7%) was found to be lower in this cohort compared to previously published cohorts, which range from 8.8% to 12.2% ( 46 - 48 , 50 ). It is interesting to note that 82.4% of patients from this systematic review are from studies published after 2020, suggesting that increased experience with TAVR in BAV may play a role in mitigating post-procedural PVL.…”