Effect of Simulated Geomagnetic Activity on Myocardial Ischemia/Reperfusion Injury in Rats

Wu, Hui Dong; Chang, Weiyu; Deng, Yanglin; Chen, Han Y. H.; Ding, Yongli; Li, Xuesong; Liang, Dong

doi:10.21470/1678-9741-2018-0306

Cited by 4 publications

(1 citation statement)

References 12 publications

(17 reference statements)

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“…It affects heart rate variability, increased blood viscosity, coagulation, and platelet aggregation [7]. In an artificially simulated magnetic field experiment with laboratory mice, the difference in myocardial ischemiareperfusion injury was observed depending on different magnetic field conditions [8]. The study revealed that myocardial ischemia-reperfusion injury was greater in mice exposed to an artificial geomagnetic field than in those isolated from the magnetic field [8].…”

Section: Literature Reviewmentioning

confidence: 99%

Correlation between ST-elevation myocardial infarction, non-ST-elevation myocardial infarction and the local Earth’s magnetic field changes

Vanagaitė¹,

Jakuškaitė²,

Žiubrytė³

et al. 2022

J., complex., health sci.

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Stronger oscillations in the local Earth magnetic field may have an impact on the course of ischemic heart disease. This effect is individual for every person and depends on the sex, age, living territory, season, capability to adjust to magnetic field fluctuations and health status. Individuals who already have cardiovascular disease are more sensitive to magnetic field fluctuations, therefore further research is needed to make conclusions. Aim: To identify correlations between changes in local Earth magnetic field frequencies and patients with ST segment elevation myocardial infarction (STEMI) and non-ST segment elevation myocardial infarction (NSTEMI) cases per week, cases by sex per week and patients’ blood laboratory parameters (low-density lipoprotein cholesterol and Troponin I level). Methods: A retrospective study of 1667 patients, who were admitted to the Hospital of Lithuanian University of Health Sciences Kaunas Clinics between 1st January and 31st December 2019 due to acute coronary syndrome (STEMI and NSTEMI), were included in the study. Local Earth's time varying magnetic field (TVMF) was measured by a magnetometer located in Baisogala, Lithuania. Data from the magnetometer was collected daily, and weekly averaged. We assessed the correlations between average weekly geomagnetic field strength in six different frequency ranges (Hz) and average number of STEMI and NSTEMI cases per week, cases by sex per week and patients’ blood laboratory parameters (low-density lipoprotein cholesterol and Troponin I level). Results: The presence of a stronger magnetic field in the frequency range of 32-65 Hz was significantly related to the number of cases in the STEMI group during the winter season (r= 0.583, p= 0.036). Tendency towards a positive correlation was found during the winter in the men's group with STEMI in the high frequency range of 32-65 Hz. Low-density lipoprotein cholesterol level correlated positively in the winter STEMI group with the magnetic field in the 32-65 Hz range, and in the autumn STEMI group with the magnetic field in the frequency range of 0-7 Hz. Conclusion: Increased geomagnetic field strength in the high frequency range of 32-65 Hz is associated with a higher number of cases in the STEMI group.

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Section: Literature Reviewmentioning

confidence: 99%

Correlation between ST-elevation myocardial infarction, non-ST-elevation myocardial infarction and the local Earth’s magnetic field changes

Vanagaitė¹,

Jakuškaitė²,

Žiubrytė³

et al. 2022

J., complex., health sci.

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Geomagnetic activity affects animal myocardial ischemia/reperfusion injury: an experimental-simulated study

Chang,

Chen,

Yang

et al. 2024

Int J Biometeorol

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Numerous studies have shown that geomagnetic activity (GMA) contributes to the development and escalation of cardiovascular disease (CVD), as well as increased morbidity and mortality. However, the underlying molecular mechanisms and approaches for understanding GMA remain unclear. This study aimed to investigate the impact of GMA on oxidative stress and inflammatory responses. Myocardial ischemia/reperfusion injury (MI/RI) rat models were created under various geomagnetic field conditions. The range of cardiac function, markers of myocardial injury, inflammatory factors, and the TLR4/NF-κB signaling pathway were measured after the 24-h period. The findings showed that weak GMA significantly improved cardiac function in the MI/RI rat model and reduced the size of myocardial infarction and creatine kinase (CK) and lactic dehydrogenase (LDH) levels. Additionally, weak GMA enhanced superoxide dismutase (SOD) activity and decreased malondialdehyde (MDA) content. Furthermore, weak GMA significantly reduced the levels of the myocardial inflammatory cytokines interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). Conversely, the effects observed under severe GMA conditions were opposite to those observed under weak GMA. Western blot and qPCR analysis demonstrated that weak GMA led to a significant downregulation of TLR4, TRAF6, NF-κB, TNF-α, and MCP-1 in the MI/RI rat models. In contrast to weak GMA, severe GMA increased TLR4, TRAF6, NF-κB, and TNF-α expression. This study suggested that weak GMA had a limiting effect on MI/RI rat models, whereas severe GMA exacerbated injury in MI/RI rats. These effects were associated with oxidative stress and inflammatory responses and might potentially involve the TLR4/NF-κB signaling pathway.

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Can we believe results obtained from plasma melatonin ELISA kits?

Kennaway

2021

Chronobiology International

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Effect of Simulated Geomagnetic Activity on Myocardial Ischemia/Reperfusion Injury in Rats

Cited by 4 publications

References 12 publications

Correlation between ST-elevation myocardial infarction, non-ST-elevation myocardial infarction and the local Earth’s magnetic field changes

Correlation between ST-elevation myocardial infarction, non-ST-elevation myocardial infarction and the local Earth’s magnetic field changes

Geomagnetic activity affects animal myocardial ischemia/reperfusion injury: an experimental-simulated study

Can we believe results obtained from plasma melatonin ELISA kits?

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