“…As chemical pleurodesis treatment we preferred to use betadine over talc. The literature warns against significant side effects in using chemical pleurodesis with talc, such as fever, chest pain [20], cough, infection at the insertion of the drain, bronchospasm, allergic reaction, arrhythmias, pulmonary edema, pneumonia, respiratory failure, and acute respiratory distress syndrome [21,22]. Other studies found even more disadvantages of talc chemical pleurodesis in malignancies, such as fixation of the lung parenchyma at the level of the pleuropericardial window, which causes pericardial constriction [23,24].…”