Effect of Plasma Level of Vitamin D on Postoperative Atrial Fibrillation in Patients Undergoing Isolated Coronary Artery Bypass Grafting

Abstract

ObjectivePostoperative atrial fibrillation (PoAF) is a common complication after coronary artery bypass grafting (CABG). The aim of the present study was to evaluate the association between development of PoAF and vitamin D levels in patients undergoing isolated CABG.MethodsThis prospective randomized clinical trial was conducted on the patients with isolated CABG. The study was terminated when 50 patients in both PoAF(+) group and PoAF(-) group were reached. Development of AF until discharge period was assessed. Vitamin D level was measured immediately after AF; it was measured on the discharge day for the patients without PoAF. Predictive values of the independent variables were measured for the development of PoAF.ResultsThe groups were separated as PoAF(-) group (66% male, mean age 58.18±10.98 years) and PoAF(+) group (74% male, mean age 61.94±10.88 years). 25(OH) vitamin D level (OR=0.855, 95% CI: 0.780-0.938, P=0.001) and > 65 years (OR=3.525, 95% CI: 1.310-9.483, P=0.013) were identified as an independent predictor of postoperative AF after CABG surgery in multivariate analysis. The cut-off level for 25(OH) vitamin D level in receiver-operating characteristic curve analysis was determined as 7.65 with sensitivity of 60% and specificity of 64% for predicting PoAF (area under the curve: 0.679, P=0.002).ConclusionVitamin D level is considered an independent predictor for development of PoAF. Lower vitamin D levels may be one of the reasons for PoAF.

Vitamin D Deficiency is not Associated with Higher Levels of SYNTAX Score

“…VitD deficiency is independently associated with cardiovascular morbidity and mortality in the general population [1] . Growing evidence demonstrates that vitD deficiency is strongly associated with various cardiovascular diseases, including postoperative atrial fibrillation and increased frequencies of HT, DM, obesity, HL, metabolic syndrome, and inflammation [2-6,17,18] . Several potential mechanisms established associations between vitD and atherosclerotic process.…”

The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies

“…Six studies with 5503 cases/66,139 participants were included [7, 9, 12, 13, 16, 18]. As shown in Fig.…”

The Status and Research Progress on Vitamin D Deficiency and Atrial Fibrillation

“…In subsequent studies, he found out that vitamin D supplementation can prevent the occurrence of POAF when vitamin D is extremely deficient [22] . The other four studies supported that vitamin D deficiency directly led to an increased incidence of POAF [23-26] . The patients enrolled in the study by Gode et al [25] and Özsin et al [26] were young, and all studies supported a left atrial diameter as an independent risk factor for POAF.…”

“…The other four studies supported that vitamin D deficiency directly led to an increased incidence of POAF [23-26] . The patients enrolled in the study by Gode et al [25] and Özsin et al [26] were young, and all studies supported a left atrial diameter as an independent risk factor for POAF. Overall evidence of vitamin D deficiency seems to support the onset of POAF.…”