2011
DOI: 10.2147/ijn.s26355
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Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely utilized for the diagnosis and therapy of specific diseases, as magnetic resonance imaging (MRI) contrast agents and drug-delivery carriers, due to their easy transportation to targeted areas by an external magnetic field. For such biomedical applications, SPIONs must have multifunctional characteristics, including optimized size and modified surface. However, the biofunctionality and biocompatibility of SPIONs with various surface functional… Show more

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Cited by 69 publications
(31 citation statements)
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“…Results clearly revealed dependence of toxicity on surface ligation. It was established that the surface of IONP could be manipulated to alter the endocytosis of nanoparticles and their subsequent toxicity (152). Similarly, coating of IONP nanoparticles with three very closely related carbohydrates i.e.…”
Section: Surface Chemistrymentioning
confidence: 99%
“…Results clearly revealed dependence of toxicity on surface ligation. It was established that the surface of IONP could be manipulated to alter the endocytosis of nanoparticles and their subsequent toxicity (152). Similarly, coating of IONP nanoparticles with three very closely related carbohydrates i.e.…”
Section: Surface Chemistrymentioning
confidence: 99%
“…Studies evidenced that the increase in apoptosis caused by CEINs was accompanied with the Bax over-expression, mitochondrial membrane potential decrease, and the release of cytochrome C from mitochondria into cytosol (Kai et al 2011). Recent toxicological observations of different groups used for surface coatings and/or modification types in MNPs suggest that some functional groups such as hydroxyl (–OH), carboxylic (–COOH), amine (–NH 2 ), and citrate are especially critical determinants of cellular responses, degrees of cytotoxicity, and potential mechanisms of toxicity (Hong et al 2011; Kai et al 2011; Unfried et al 2007). Surface functional groups (–COOH or –NH 2 ) also determined the toxic potential of graphene and carbon nanotubes (Jain et al 2011; Singh et al 2011).…”
Section: Introductionmentioning
confidence: 99%
“…To data, amine-modified single-walled carbon nanotubes were also found to protect neurons from injury in rats (Lee et al 2011). In addition to surface modifications in MNPs, some unique physicochemical properties of nanoparticles, such as shape and size might also play a critical role in producing cytotoxic effects, and plausibly influences aggregation states during in vitro examinations of MNPs and graphene nanoparticles in cell culture models (Akhavan et al 2012; Hong et al 2011). It was noted that iron oxide nanoparticles coated with negatively charged citrate ligands were destabilized in cell culture media and interacted strongly with human lymphoblastoid cells (Safi et al 2011).…”
Section: Introductionmentioning
confidence: 99%
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“…The coated system acts as cross-linker of the CMC polysaccharide chains by forming amido covalent bonds. While CMC safety and biodegradability are well established [12], the compatibility and safety of magnetic silanized NPs is controversial [13, 14]. …”
Section: Introductionmentioning
confidence: 99%