No association between vitamin D status and COVID-19 infection in São Paulo, Brazil

Brandão, Cynthia; Chiamolera, Maria Izabel; Biscolla, Rosa Paula M.; Lima, Jose Viana; Ferrer, Claudia; Prieto, Wesley Heleno; Russo, Pedro; Sá, José de; Lazari, Carolina dos Santos; Granato, Celso Francisco Hernandes; Vieira, José Gilberto H.

doi:10.20945/2359-3997000000343

Cited by 17 publications

(15 citation statements)

References 20 publications

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“…Some studies did not find any relationship between the serum level of 25-hydroxyvitamin D and the severity of COVID-19 disease and mortality. In a retrospective population-based study in Brazil, 14,692 people who recently measured serum levels of 25(OH)D and had RT-PCR test for COVID-19 were studied 53 . There was no significant difference between PCR positive and PCR negative individuals in mean 25(OH)D levels and the prevalence of vitamin D deficiency.…”

Section: Discussionmentioning

confidence: 99%

The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality

Vasheghani

Jannati

Baghaei

et al. 2021

Sci Rep

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Supplemental vitamin D can reduce the risk and mortality of viral pneumonia. The relationship between 25 hydroxyvitamin D [25(OH)D] levels and the severity and mortality of Coronavirus disease 2019 (COVID-19) was evaluated. In this cross-sectional study, the admitted patients with COVID-19 were categorized as mild, moderate, severe, and critical based on clinical and radiologic characteristics. Calcium, phosphorus, albumin, creatinine, and serum 25(OH)D were measured and their correlation with the severity of disease and mortality were analyzed. During 2 months, 508 patients (442 patients in general wards and 66 patients in the intensive care unit (ICU)) were included. The participants were 56 ± 17 years old (52% male, 37% with comorbidity). Concerning severity, 13%, 42%, 36%, and 9% had mild, moderate, severe, and critical diseases, respectively. The mortality rate was 10.8%. Admission to ICU, severity of disease and mortality decreased significantly across quartiles of 25(OH)D. According to multivariate logistic regression analysis, disease mortality had a positive correlation with age and had a negative correlation with the serum level of 25(OH)D, calcium, and albumin. In hospitalized patients with COVID-19, low 25(OH)D was associated with severe disease and increased ICU admission and mortality rate.

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Section: Discussionmentioning

confidence: 99%

The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality

Vasheghani

Jannati

Baghaei

et al. 2021

Sci Rep

View full text Add to dashboard Cite

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“…However, the studies included in these systematic reviews exhibited a high risk of various biases, such as inadequate evaluation of the outcome, inappropriate sample selection, and lack of uniformity of the inclusion criteria, and so the certainty of evidence emerging from these studies appears low. On the contrary, a study from Italy ( 14 ) and another from Brazil ( 15 ) clearly refute the probability of a causal link between vitamin D deficiency and susceptibility to SARS-CoV-2 infection. Therefore, it is imperative to have more evidence based on large population-based studies to reveal the risk of COVID-19 in populations with vitamin D deficiency, and multicenter randomized controlled trials to observe the potential benefits of vitamin D supplementation in treating the disease.…”

mentioning

confidence: 97%

Vitamin D Deficiency Is Associated With Higher Hospitalization Risk From COVID-19: A Retrospective Case-control Study

Jude

Ling

Allcock

et al. 2021

The Journal of Clinical Endocrinology &Amp; Metabolism

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CONTEXT One of the risk factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is postulated to be vitamin D deficiency. To understand better the role of vitamin D deficiency in the disease course of COVID-19, we undertook a retrospective case-control study in the North West of England (NWE). OBJECTIVE To examine whether hospitalisation with COVID-19 is more prevalent in individuals with lower vitamin D levels. METHODS The study included individuals with results of serum 25-hydroxyvitamin D (25[OH]D) between 1 st April 2020 and 29th January 2021. Patients were recruited from two districts in NWE. The last 25(OH)D level in the previous 12 months was categorised as ‘deficient’ if less than 25 nmol/L and ‘insufficient’ if 25-50 nmol/L. RESULTS 80,670 participants were entered into the study. Of these, 1,808 were admitted to hospital with COVID-19, of whom 670 died. In a primary cohort, median serum 25(OH)D in participants who were not hospitalised with COVID-19 was 50.0 [interquartile range, IQR 34.0-66.7] nmol/L versus 35.0 [IQR 21.0-57.0] nmol/L in those admitted with COVID-19 (p <0.005). There were similar findings in a validation cohort (median serum 25(OH)D 47.1 [IQR 31.8-64.7] nmol/L in non-hospitalised versus 33.0 [IQR 19.4-54.1] nmol/L in hospitalised patients). Age-, sex- and seasonal variation-adjusted odds ratios for hospital admission were 2.3-2.4 times higher among participants with serum 25(OH)D <50 nmol/L, compared to those with normal serum 25(OH)D levels, without any excess mortality risk. CONCLUSIONS Vitamin D deficiency is associated with higher risk of COVID-19 hospitalisation. Widespread measurement of serum 25(OH)D and treating any unmasked insufficiency or deficiency through testing may reduce this risk.

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“…Baseline VD status seems not to influence the risk of contracting SARS-CoV-2 infection, as recently published from Brazil [167]. In other words, a sufficient VD status may fail to protect against SARS-CoV-2 infection.…”

Section: Parathyroid Glands and Calcium-phosphorus Metabolismmentioning

confidence: 58%

COVID-19 and the Endocrine System: A Comprehensive Review on the Theme

Lisco

Tullio

Stragapede

et al. 2021

JCM

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: Background and aim. The review aimed to summarize advances in the topic of endocrine diseases and coronavirus disease 2019 (COVID-19). Methods. Scientific and institutional websites and databases were searched and data were collected and organized, when plausible, to angle the discussion toward the following clinical issues. (1) Are patients with COVID-19 at higher risk of developing acute or late-onset endocrine diseases or dysfunction? (2) May the underlying endocrine diseases or dysfunctions be considered risk factors for poor prognosis once the infection has occurred? (3) Are there defined strategies to manage endocrine diseases despite pandemic-related constraints? Herein, the authors considered only relevant and more frequently observed endocrine diseases and disorders related to the hypothalamic-pituitary region, thyroid and parathyroid glands, calcium-phosphorus homeostasis and osteoporosis, adrenal glands, and gonads. Main. Data highlight the basis of some pathophysiological mechanisms and anatomical alterations of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-induced endocrine dysfunctions. Some conditions, such as adrenal insufficiency and cortisol excess, may be risk factors of worse clinical progression once the infection has occurred. These at-risk populations may require adequate education to avoid the SARS-CoV-2 infection and adequately manage medical therapy during the pandemic, even in emergencies. Endocrine disease management underwent a palpable restraint, especially procedures requiring obligate access to healthcare facilities for diagnostic and therapeutic purposes. Strategies of clinical triage to prioritize medical consultations, laboratory, instrumental evaluations, and digital telehealth solutions should be implemented to better deal with this probably long-term situation.

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No association between vitamin D status and COVID-19 infection in São Paulo, Brazil

Cited by 17 publications

References 20 publications

The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality

The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality

Vitamin D Deficiency Is Associated With Higher Hospitalization Risk From COVID-19: A Retrospective Case-control Study

COVID-19 and the Endocrine System: A Comprehensive Review on the Theme

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