2021
DOI: 10.20945/2359-3997000000335
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Abstract: Hypopituitarism is a disorder characterized by insufficient secretion of one or more pituitary hormones. New etiologies of hypopituitarism have been recently described, including head trauma, cerebral hemorrhage, and drug-induced hypophysitis. The investigation of patients with these new disorders, in addition to advances in diagnosis and treatment of hypopituitarism, has increased the prevalence of this condition. Pituitary hormone deficiencies can induce significant clinical changes with consequent increased… Show more

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Cited by 6 publications
(11 citation statements)
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“…In addition to exogenous corticosteroids, diverse conditions may also result in CAI (Table 2). Traumatic brain injury (TBI) is related to hypopituitarism in the frequency range of 16% to 69% (20), which could be dependent on patient selection, evaluation during different times along the disease course, TBI severity, diagnostic criteria, dynamic stimulation testing methods, and diagnostic cut-off values (20,21). A meta-analysis including 66 studies (besides high heterogeneity index = I² >75%) showed that TBI was related to hypopituitarism (any pituitary axis) in a large range spanning 5% to 90%, but the prevalence of CAI due to TBI ranges from 7% to 13% (22).…”
Section: Who?mentioning
confidence: 99%
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“…In addition to exogenous corticosteroids, diverse conditions may also result in CAI (Table 2). Traumatic brain injury (TBI) is related to hypopituitarism in the frequency range of 16% to 69% (20), which could be dependent on patient selection, evaluation during different times along the disease course, TBI severity, diagnostic criteria, dynamic stimulation testing methods, and diagnostic cut-off values (20,21). A meta-analysis including 66 studies (besides high heterogeneity index = I² >75%) showed that TBI was related to hypopituitarism (any pituitary axis) in a large range spanning 5% to 90%, but the prevalence of CAI due to TBI ranges from 7% to 13% (22).…”
Section: Who?mentioning
confidence: 99%
“…Nonetheless, under clinical suspicion of CAI, basal measurement of cortisol levels is recommended. In these cases, basal cortisol ≤ 88 nmol/L (3 μg/dL) confirms CAI, while 415 nmol/L (15 μg/dL) or more excludes CAI (19,20). Values between 88 nmol/L (3 μg/dL) and 415 nmol/L (15 μg/dL) will require dynamic tests to evaluate corticotroph axis integrity (20,32).…”
Section: Basal Cortisol Measurementmentioning
confidence: 99%
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