Clinical utility of TGFB1 and its receptors (TGFBR1 and TGFBR2) in thyroid nodules: evaluation based on single nucleotide polymorphisms and mRNA analysis

Peres, Karina Colombera; Teodoro, Larissa; Amaral, Laís Helena Pereira; Teixeira, Elisângela Souza; Barreto, Icléia Siqueira; Freitas, Leandro Luiz Lopes de; Máximo, Valdemar; Assumpção, Lígia Vera Montali da; Bufalo, Natassia Elena; Ward, Laura Sterian

doi:10.20945/2359-3997000000330

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…and FTA histological types [29]. In our study, TGFBR2 was decreased in both thyroid and parathyroid adenomas, corresponding to the above findings.…”

Section: Accepted Manuscriptsupporting

confidence: 90%

“…affected the risk of cancer and observed that TGFBR2 was downregulated in both papillary thyroid cancer (PTC) and FTA histological types [29]. In our study, TGFBR2 was decreased in both thyroid and parathyroid adenomas, corresponding to the above findings.…”

Section: Peres Et Al Studied How Single Nucleotide Polymorphisms (Snps)supporting

confidence: 83%

“…In a genetic study, TGFBR2 was detected in thyroid-associated eye disease 28 . Peres et al studied how single nucleotide polymorphisms (SNPs) affected the risk of cancer and observed that TGFBR2 was downregulated in both papillary thyroid cancer (PTC) and FTA histological types 29 . In our study, TGFBR2 was decreased in both thyroid and parathyroid adenomas, corresponding to the above findings.…”

Section: Discussionmentioning

confidence: 99%

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Common Key Genes in Differentiating Parathyroid Adenoma From Thyroid Adenoma

Lin

Mou

et al. 2023

Horm Metab Res

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Recent studies have demonstrated the close relationship between parathyroid adenoma(PA) and thyroid follicular adenoma(FTA). However, the underlying pathogenesis remains unknown. This study focused on exploring common pathogenic genes, as well as the pathogenesis of these two diseases, through bioinformatics methods. This work obtained PA and FTA datasets from the Integrated Gene Expression Database to identify the common differentially expressed genes (DEGs) of two diseases. The functions of the genes were investigated by GO and KEGG enrichment. The program CytoHubba was used to select the hub genes, while receiver operating characteristic curves were plotted to evaluate the predictive significance of the hub genes. The DGIbd database was used to identify gene-targeted drugs. This work detected a total of 77 DEGs. Enrichment analysis demonstrated that DEGs had activities of 3’,5'-cyclic AMP, and nucleotide phosphodiesterases and were associated with cell proliferation. NOS1, VWF, TGFBR2, CAV1, and MAPK1 were identified as hub genes after verification. The area under the curve of PA and FTA was > 0.7, and the hub genes participated in the Relaxin Signaling Pathway, focal adhesion, and other pathways. The construction of the mRNA-miRNA interaction network yielded 11 important miRNAs, while gene-targeting drug prediction identified four targeted drugs with possible effects. This bioinformatics study demonstrated that cell proliferation and tumor suppression, the hub genes co-occurring in PA and FTA, have important effects on the occurrence and progression of two diseases, which make them potential diagnostic biomarkers and therapeutic targets.

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“…and FTA histological types [29]. In our study, TGFBR2 was decreased in both thyroid and parathyroid adenomas, corresponding to the above findings.…”

Section: Accepted Manuscriptsupporting

confidence: 90%

Section: Peres Et Al Studied How Single Nucleotide Polymorphisms (Snps)supporting

confidence: 83%