2020
DOI: 10.20945/2359-3997000000313
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Abstract: Deleterious effects of free fatty acids, FFAs, on insulin sensitivity are observed in vivo studies in humans. Mechanisms include impaired insulin signaling, oxidative stress, inflammation, and mitochondrial dysfunction, but the effects on insulin secretion are less well known. Our aim was to review the relationship of increased FFAs with insulin resistance, secretion and mainly with the incretin effect in humans. Narrative review. Increased endogenous or administered FFAs induce insulin resistance. FFAs effect… Show more

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Cited by 16 publications
(13 citation statements)
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“…At day 21, ZENlow and ZENhigh animals showed significantly lower FFA levels. There is a relationship between circulating levels of FFA and glucose metabolism, as high FFA serum levels are often related with the development of insulin resistance [30]. In the present study, animal groups showing lower FFA levels also exhibited lower glucose levels, suggesting a likely insulin-mediated mechanism for both effects.…”
Section: Discussionsupporting
confidence: 53%
“…At day 21, ZENlow and ZENhigh animals showed significantly lower FFA levels. There is a relationship between circulating levels of FFA and glucose metabolism, as high FFA serum levels are often related with the development of insulin resistance [30]. In the present study, animal groups showing lower FFA levels also exhibited lower glucose levels, suggesting a likely insulin-mediated mechanism for both effects.…”
Section: Discussionsupporting
confidence: 53%
“…In addition, the changes in the plasma free fatty acid level correlated linearly with intramyocellular triglyceride (r = 0.74, p < 0.003) [ 63 ]. The free fatty acid impairment of insulin sensitivity has been repeatedly reported [ 64 ]. The composition of a fatty acid diet could have a significant role in modulating IR.…”
Section: Discussionmentioning
confidence: 99%
“…SFAs levels, in particular palmitic acid, are elevated in obese patients, and correlate with a risk of developing T2D [ 322 ]. Notably, chronic elevated palmitic acid levels have detrimental effects on β-cell function by reducing both GSIS and the insulinotropic effects of the incretin hormones [ 323 , 324 , 325 ]. A detrimental role has also been demonstrated for saturated stearic acid [ 326 ].…”
Section: Dysfunctional Adipose Tissue Secretome Affects β-Cell Functi...mentioning
confidence: 99%