2019
DOI: 10.20945/2359-3997000000184
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Abstract: Growth hormone (GH) is best known for its effect stimulating tissue and somatic growth through the regulation of cell division, regeneration and proliferation. However, GH-responsive neurons are spread over the entire central nervous system, suggesting that they have important roles in the brain. The objective of the present review is to summarize and discuss the potential physiological importance of GH action in the central nervous system. We provide evidence that GH signaling in the brain regulates the physi… Show more

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Cited by 28 publications
(17 citation statements)
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References 61 publications
(106 reference statements)
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“…Another substantial number of GHR-expressing neurons were distributed in the thalamus region. These observations are consistent with the expected expression pattern of GHR in the brain (8,12,13), and for the first time enabled us to study the function of specific GHR populations throughout the brain.…”
Section: Discussionsupporting
confidence: 86%
See 3 more Smart Citations
“…Another substantial number of GHR-expressing neurons were distributed in the thalamus region. These observations are consistent with the expected expression pattern of GHR in the brain (8,12,13), and for the first time enabled us to study the function of specific GHR populations throughout the brain.…”
Section: Discussionsupporting
confidence: 86%
“…The distribution of GHR-expressing neurons in the brain by GHR dTom reporter resembles that determined by in situ hybridization and by systemic GH injections followed by pSTAT5 expression pattern in the brain (8,12,13). Large populations of GHR-expressing neurons lay in the hypothalamus, especially in the ARC, DMH, and VMH; other substantial populations reside in the posterior hypothalamic area and ventral pre-mammillary nucleus.…”
Section: Discussionmentioning
confidence: 58%
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“…However, our research group mapped the distribution of GH‐responsive cells in the mouse brain (Furigo, Metzger, Teixeira, Soares, & Donato Jr., 2017) and found a much broader distribution of cells that respond directly to GH than previously acknowledged. Besides the regulation of the somatotropic axis (Wasinski et al, 2020), GH action in the hypothalamus has been recently associated with the central control of metabolism (Wasinski, Frazão, & Donato, 2019). GH receptor (GHR) ablation in different neural populations promotes changes in food intake, energy expenditure, body adiposity, glucose homeostasis, and remarkably also in the response to situations of metabolic stress (Bohlen et al, 2019; Furigo et al, 2019a; Furigo et al, 2019b; Quaresma et al, 2019; Teixeira et al, 2019).…”
Section: Introductionmentioning
confidence: 99%