Is there any association between vitamin D levels and polycystic ovary syndrome (PCOS) phenotypes?

Eftekhar, Maryam; Mirhashemi, Elham Sadat; Molaei, Behnaz; Pourmasumi, Soheila

doi:10.20945/2359-3997000000177

Cited by 12 publications

(13 citation statements)

References 22 publications

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“…Our results point out the role of vitamin D in the pathogenesis of PCOS.Vitamin D by itself can be a cause of PCOS. Evidences verify that vitamin D plays an essential role in reproductive activities and that the reproductive system, including ovaries, the endometrium, and the placenta, has receptors forvitamin D. Also, it has been found that calcium dysregulation, a condition related to vitamin D deficiency, is responsible for the increase in the follicular arrest and results in menstrual and fertility disorders in women with PCOS [22].ThePCOS group in our study had a significantly lower vitamin D concentration than the control group. Only 6.89% of PCOS patients and 10.34% of controls in our study had HTN (Table 1) and they lied in the vitamin D deficient category only (Table 5).…”

Section: Resultsmentioning

confidence: 99%

“…Despite this, there is no agreement on the differences in serum vitamin D levels among women having and not having PCOS. Many studies reported that vitamin D of patients with PCOS wasinversely correlated with metabolic disturbances [9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Increased risk of PCOS or its associated endocrine/metabolic disturbances were linked with polymorphism of vitamin D receptor gene, which presents the effect of vitaminD in PCOS pathogenesis [12,13,16].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Vitamin D Deficiency in Polycystic Ovarian Syndrome

Al-Ghanny

Al-Moosawi

Ahmed

2022

eijs

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Polycystic ovary syndrome is a very common cause of female infertility. This study aims to assess the prevalence of vitamin D deficiency and its association with clinical and anthropometric characteristics of Iraqi women with and without polycystic ovary syndrome. Fifty eightwomen with the disease and their matched control group were included. Their blood pressure was measured. Serum level of 25 hydroxy vitamin D of <20 ng/mL was graded as vitamin D deficiency. The polycystic ovary syndrome group had significantly lower levels of 25 hydroxy vitamin D, higher body mass index, and higher waist to hip ratio in contrast to the control group. The difference in body mass index was more significant in the obese category. Within subjects with the waist to hip ratio of ≥0.85, who were all vitamin D deficient, vitamin D was significantly lower and waist to hip ratio was significantly higher in patients than in controls. Vitamin D levels were significantly lower in patients than in controls in the non-hypertensive category. Further studies are needed to investigate the role of vitamin D in the pathogenesis of polycystic ovary syndrome.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Vitamin D Deficiency in Polycystic Ovarian Syndrome

Al-Ghanny

Al-Moosawi

Ahmed

2022

eijs

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“…This was in agreement with Eftekhar et al study. 9 They showed that AMH was significantly higher in PCO patients. Also, Bhide et al showed that women with PCO morphology had significantly higher AMH levels than women in the control group.…”

Section: Discussionmentioning

confidence: 98%

“…Moreover, Eftekhar et al study showed that a lower serum VD level in the PCOS patients than in control patients (p<0.001). 9 This may be contributed to ethnic group or geographical factors or different lifestyle.…”

Section: Discussionmentioning

confidence: 99%

Relationship between vitamin D3 deficiency and polycystic ovarian syndrome

Elsadany

Elshwaikh

Borg

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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Background: Vitamin D3 (VD3), a seco-steroid that is synthesized in skin and sequentially metabolized in liver and kidneys in humans, has been well-known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. Polycystic ovary syndrome (PCOS) is a common cause of ovarian dysfunction in women with anovulation. Aim of this study is to show and evaluate VD3 level in women who are suffering from polycystic ovarian syndrome.Methods: This study was conducted on 200 women; group A: (study group) 100 infertile women who were suffering from PCOS and group B: (control group) 100 patients were selected with other cause of infertility than PCOS. US examination, hormonal profile (FSH, LH, AMH, TSH and prolactin level) and laboratory assay of serum VD3 level (postmenstrual) were done for every patient to evaluate relationship between VD3 deficiency and PCOS patients.Results: There was a significant relationship between group A compared to group B as regards irregular menstrual cycle, clinical hyperandrogenism, LH/FSH ratio and AMH. There was no significant difference between both groups as regards TSH, prolactin and VD3 level. VD was deficient in both groups as it was lower than normal level. There was a negative significant correlation between VD3 level and both hyperandrogenism and AMH.Conclusions: There was VD3 deficiency in PCO patients and infertile cases due to another factor, and negative significant correlation between VD3 level and clinical hyperandrogenism, LH/FSH ratio, menstrual cycle and AMH.

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“…Проводились исследования и по оценке уровня витамина D в сыворотке крови у пациенток с СПКЯ в зависимости от фенотипа заболевания, однако достоверных различий в уровне витамина D при различных фенотипах СПКЯ не обнаружено [42].…”

Section: лечениеunclassified

Specificities of the treatment for polycystic ovary syndrome and metabolic syndrome

Il’ina¹

2020

Russian Journal of Woman and Child Health

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This paper discusses polycystic ovary syndrome (PCOS), a common endocrine disorder characterized by hirsutism, anovulation, and polycystic ovaries. Insulin resistance which is considered the major causative factor for both PCOS and metabolic syndrome is emphasized. The early diagnosis of metabolic disorders which increase the risk of cardiovascular complications and the complications of pregnancy (including gestational diabetes and hypertension which may result in preeclampsia and placental abruption) is of particular importance. The presence of metabolic syndrome in PCOS is associated with poor prognosis in terms of fertility and has a negative impact on the outcomes of in vitro fertilization in infertile women with PCOS. When describing treatment approaches, the role of metformin, inositol, folates, vitamin D, and statins in treating metabolic disorders in PCOS and metabolic syndrome, reducing the risks of cardiovascular complications, and realizing fertile function is highlighted. The course of PCOS is complicated by psychic disorders (i.e., depression, anxiety, bipolar disorder, or eating disorders) which are common in these women and should be considered when prescribing medications. KEYWORDS: polycystic ovary syndrome, insulin resistance, infertility, metabolic syndrome, cardiovascular complications, inositol, folates. FOR CITATION: Il’ina I.Yu. Specificities of the treatment for polycystic ovary syndrome and metabolic syndrome. Russian Journal of Woman and Child Health. 2020;3(4):254–259. DOI: 10.32364/2618-8430-2020-3-4-254-259.

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Is there any association between vitamin D levels and polycystic ovary syndrome (PCOS) phenotypes?

Cited by 12 publications

References 22 publications

Effects of Vitamin D Deficiency in Polycystic Ovarian Syndrome

Effects of Vitamin D Deficiency in Polycystic Ovarian Syndrome

Relationship between vitamin D3 deficiency and polycystic ovarian syndrome

Specificities of the treatment for polycystic ovary syndrome and metabolic syndrome

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