Low serum 25-hydroxy vitamin D levels are associated with aggressive breast cancer variants and poor prognostic factors in patients with breast carcinoma

Karthikayan, Arunkumar; Sureshkumar, Sathasivam; Dharanipragada, Kadambari; Vijayakumar, Chellappa

doi:10.20945/2359-3997000000062

Cited by 22 publications

(11 citation statements)

References 17 publications

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“…Another case control study in Asian women also suggests potential preventive effect of vitamin D on breast cancer for Korean women [57]. Similar findings of protective role of vitamin D against breast cancer are reported from studies in Indian populations [52,58]. Two studies done in Pakistan have only descriptive analysis in one [59] and small sample size in the other study [60].…”

Section: Introductionsupporting

confidence: 57%

A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan

et al. 2020

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Background The prevalence of vitamin D inadequacy and breast cancer are both high among women living in Karachi, Pakistan. Methods A matched case control study was conducted in two hospitals of Karachi, Pakistan to evaluate the association of vitamin D (serum 25-hydroxyvitamin D) concentrations, vitamin D supplementation and sun exposure with breast cancer among Pakistani women. A total of 411 newly diagnosed histologically confirmed primary breast cancer cases were enrolled and 784 controls, free of breast and any other cancers, were matched by age (year of birth ± 5 years), residence in the same geographic area and study site. Information was collected on sociodemographic history, history of vitamin D supplementation, past medical and obstetrical history, family history of breast cancer, sun exposure history, histopathology reports and anthropometric measurement and venous blood was collected to measure serum 25-hydroxyvitamin D (25(OH)D) concentration. Results Compared to patients with sufficient serum vitamin D (>30 ng/ml), women with serum vitamin D deficiency (<20ng/ml), had a higher risk of breast cancer (OR = 1.65, 95%CI: 1.10, 2.50). Women with history of vitamin D supplementation one year prior to enrollment, had significant protective effect against breast cancer (OR = 0.32, 95% CI: 0.24, 0.43). Conclusions and recommendation Serum vitamin D deficiency was associated with increased risk of breast cancer, while vitamin D supplementation was associated with decreased risk of breast cancer.

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Section: Introductionsupporting

confidence: 57%

A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan

et al. 2020

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“…6 Another study referred by Arunkumar Karthikayan et al concluded that low level of 25(OH)D in women was associated with aggressive breast cancer phenotypes. 34 According to a case control study an inverse relationship existed between breast carcinoma and serum vitamin D level that was taken after breast cancer diagnosis but different results were obtained in a prospective study where measurements were taken long before diagnosis. 29 A case control study held in Dow University Hospital in 2017 revealed that vitamin D levels were lower in breast cancer patients (85.7%) as compared to healthy females (55.8%).…”

Section: Resultsmentioning

confidence: 99%

Relation of Vitamin D Deficiency with Breast Cancer Staging in Patients from INMOL Cancer Hospital

Butt

2021

Proceedings S.Z.M.C

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Introduction: Vitamin D deficiency can be critical and is reported to be as one of the factors for development and progression of breast carcinoma. Aims & Objectives: To measure and compare 25(OH)D (calcidiol) levels in healthy females and in breast carcinoma patients in four different stages. Place and duration of study: This cross sectional study and research was conducted in Shaikh Zayed Medical Complex in the Department of Biochemistry and Chemical Pathology from Jan 2018 to Jan 2019. The patients were selected from INMOL Cancer Hospital, Lahore. Material & Methods: The study was carried out on 39 healthy females (controls) and 156 newly diagnosed cases of carcinoma breast from stage I to IV, 39 patients of each stage. 25(OH)D was determined in blood samples of patients by ADVIA Centaur (XP) immunoassay system. Results: In this study the mean 25(OH)D level of healthy females with mean age of 41.7 ± 15.8 years, was 25.1 ± 5.5ng/ml. 25(OH) D level of breast cancer patients was found to be decreasing with stage progression. For the stage I the average 25(OH)D level was 12.31ng/ml, stage II was 9 ng/ml, stage III was 8.3 ng/ml and stage IV was 8.4 ng/ml. Conclusion: It was found that healthy group of females had higher values of serum vitamin D levels as compared to breast carcinoma patients. Low concentration of serum vitamin D may contribute to the progression of stage of breast carcinoma.

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“…The role of vitamin D in tumour differentiation is well established in colon and breast cancer. It has been found that poorly differentiated cancers have a lower level of vitamin D compared to well-differentiated variants in colon and breast malignancies [ 32 , 33 ]. Studies have proven that there is a significant difference in the expression of vitamin D receptors and vitamin D deficiency between premalignant and malignant gastric cancer cells [ 31 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Association between serum 25-hydroxy vitamin D level and gastric adenocarcinoma – a cross sectional study

Kevin¹,

Anandhi²,

Lakshminarayanan³

et al. 2021

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Introduction: Vitamin D is found to have anti-cancer properties. Although the preventive role of vitamin D in cancer is proven, its role in gastric cancer is equivocal.Aim: To evaluate vitamin D deficiency in patients with gastric adenocarcinoma and its relationship with the disease characteristics.Material and methods: This single-centre, prospective, cross sectional study was carried out from February 2017 to December 2018. Serum 25-hydroxy vitamin D levels of 94 patients with gastric adenocarcinoma and 94 age-and sex-matched healthy controls were estimated. Among cases, vitamin D levels and disease characteristics such as TNM stage, tumour grade, clinical stage and patient demographics were analysed.Results: The vitamin D levels among cases (13.83 ±5.97 ng/ml) were significantly lower (p < 0.0001) than the control group (29.15 ±4.13 ng/ml). Vitamin D deficiency was found in 88% of cases and in 3% of controls. Among cases, age, T stage and clinical stage had a significant inverse relationship with vitamin D levels. Cases with distant metastasis and cases with pain had significantly lower levels of vitamin D compared to the cases without distant metastasis and without pain respectively. Other study parameters did not have a significant relationship with vitamin D.Conclusions: Vitamin D deficiency is associated with occurrence of gastric adenocarcinoma and correlates with the disease severity. However, to assign a causal relationship and to study the beneficial effect of vitamin D in gastric cancer, further research is needed.

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Low serum 25-hydroxy vitamin D levels are associated with aggressive breast cancer variants and poor prognostic factors in patients with breast carcinoma

Cited by 22 publications

References 17 publications

A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan

A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan

Relation of Vitamin D Deficiency with Breast Cancer Staging in Patients from INMOL Cancer Hospital

Association between serum 25-hydroxy vitamin D level and gastric adenocarcinoma – a cross sectional study

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