2018
DOI: 10.20945/2359-3997000000060
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Abstract: Objective: This study evaluated the effects of combination therapy of curcumin and alendronate on BMD and bone turnover markers in postmenopausal women with osteoporosis. Subjects and methods: In a randomized, double-blind trial study, 60 postmenopausal women were divided into three groups: control, alendronate, and alendronate + curcumin. Each group included 20 patients. Total body, total hip, lumbar spine and femoral neck BMDs were measured by dual-energy X-ray absorptiometry (DXA) at baseline and after 12 m… Show more

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Cited by 32 publications
(34 citation statements)
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“…Numerous clinical studies have demonstrated the potentially beneficial effects of curcumin for treating chronic inflammation (Maulina et al, 2018; Panahi et al, 2014). Curcumin increased bone mineral density in postmenopausal women with osteoporosis and reduced pain‐related symptoms in patients with osteoarthritis (Haroyan et al, 2018; Khanizadeh et al, 2018). Another clinical study validated the efficacy of curcumin in the treatment of RA by demonstrating that curcumin significantly improved symptoms and biomarkers associated with RA (Amalraj et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Numerous clinical studies have demonstrated the potentially beneficial effects of curcumin for treating chronic inflammation (Maulina et al, 2018; Panahi et al, 2014). Curcumin increased bone mineral density in postmenopausal women with osteoporosis and reduced pain‐related symptoms in patients with osteoarthritis (Haroyan et al, 2018; Khanizadeh et al, 2018). Another clinical study validated the efficacy of curcumin in the treatment of RA by demonstrating that curcumin significantly improved symptoms and biomarkers associated with RA (Amalraj et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Many studies show evidence that curcumin is beneficial for enhancing bone mineral density, improving bone microarchitecture, protecting against ovariectomy-induced bone loss, and preventing osteoporosis and arthritis [40,41,42,43,44,45]. These findings suggest that curcumin may induce bone remodeling through an inhibition or induction of osteocyte differentiation.…”
Section: Curcumin’s Effects On Osteogenic Differentiationmentioning
confidence: 99%
“…Hatefi et al administered 110/mg/kg/day curcumin to patients for 6 months and observed a significant increase in the bone mineral density (BMD) of the patients [40]. In another clinical study, dual-energy X-ray absorptiometry on 20 patients treated with curcumin for 12 months showed decreased bone-specific alkaline phosphatase (ALP) and C-terminal cross-linking telopeptide of type I collagen (CTx) levels and increased osteocalcin (OCN) and bone mineral density (BMD) indexes [45]. Additionally, for the treatment of osteopenia, patients received oral supplementation containing 1000 mg of phospholipidated (phytosomal) curcumin (containing 200 mg curcumin) for 6 months and increased bone density was reported [41].…”
Section: Summary and Clinical Applicationsmentioning
confidence: 99%
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“…For millennia, the turmeric rhizome (Curcuma longa L.) has been a staple of Ayurvedic medicine, especially for the treatment of inflammatory disorders, including arthritis 1,2 . In more recent decades, bone protective effects of curcumin, the most abundant turmeric polyphenol, have been documented in vivo in humans 3,4 and in pre-clinical models of arthritis and other common bone resorptive disorders, including osteoporosis and osteolytic bone metastases [5][6][7][8][9][10][11] . These effects have been attributed to local actions of curcumin within the bone microenvironment that inhibit the formation of bone-resorbing osteoclasts 5,10,12,13 .…”
Section: Introductionmentioning
confidence: 99%