Ethanol extract of Cissampelos sympodialis ameliorates lung tissue damage in streptozotocin-induced diabetic rats

A number of health-promoting properties of Stevia rebaudiana Bertoni and its glycosides, including the antihyperglycemic activity, have been found. The mechanisms of the antidiabetic action of stevia have not been fully understood. The aim of this study was to evaluate the effects of supplementary steviol glycosides on high-fat fed streptozotocin-induced diabetic rats with particular attention to lipid metabolism. The experiment was conducted on 70 male Wistar rats, of which 60 were fed a high-fat diet for 8 weeks followed by intraperitoneal injection of streptozotocin, to induce type 2 diabetes. Afterwards, rats were divided into six groups and fed a high-fat diet supplemented with pure stevioside or rebaudioside A, at two levels (500 or 2500 mg/kg body weight (b.w.)) for 5 weeks. Three additional groups: diabetic untreated, diabetic treated with metformin, and healthy, served as respective controls. Blood and dissected internal organs were collected for hematological, biochemical, and histopathological tests. It was found that dietary supplementation with steviol glycosides did not affect blood glucose, insulin, and insulin resistance indices, antioxidant biomarkers, but normalized hyperlipidemia and affected the appetite, as well as attenuated blood liver and kidney function indices, and reduced tissular damage in diabetic rats. Steviol glycosides normalize lipid metabolism and attenuate internal organs damage in diabetes.

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“…This shows that SGs affect appetite control (vide infra). Similar effects were reported by other authors [ 41 , 42 ].…”

Section: Discussionsupporting

confidence: 92%

Steviol Glycosides Supplementation Affects Lipid Metabolism in High-Fat Fed STZ-Induced Diabetic Rats

2020

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“…Additionally, morphological alterations such as inflammatory infiltrate, alveolar septa loss and fibrosis were found in lung tissue of rats with diabetes mellitus, and treatment with the extract of C. sympodialis apparently reversed these histopathological findings. Thus, the extract of C. sympodialis treatment reduced lipid profiles and restored lung architecture of diabetic animals through a mechanism independent of glycemia, which might be related to the decreasion of the damage on the islet cells [67] . The hydro‐alcoholic extract of C. pareira leaves has showed antidiabetic action in streptozotocin induced diabetic rats.…”

Section: Pharmacological Activitiesmentioning

confidence: 89%

“…In Medeiros et al .’s study, the purpose of this study was to investigate the effect of C. sympodialis extract on the lung tissue of diabetic rats. In addition, the extract treatment significantly reversed the histomorphological changes in the lung, such as loss of alveolar septum, inflammatory infiltration, and fibrosis in diabetes mellitus rats [67] . The effect of the alcoholic fraction of C. sympodialis leaves and its isolated alkaloid, warifteine ( 8 ) on anxiety and asthma‐like symptoms induced by ovalbumin in mice with allergic airway disease was evaluated.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

“…Previous chemical investigations have showed that alkaloids were the major secondary metabolites of the genus Cissampelos. Up to now, a total number of80 alkaloids have been isolated and identified from C. pareira [20] toberberinic alkaloids (62-65), five tropoloisoquinolinic alkaloids (66)(67)(68)(69)(70), two azafluorantene alkaloids (71 -72), two stephaoxocane alkaloids (73)(74), three pro-aporphic alkaloids (75 -77) one monoterpenoid indole alkaloid (78), one phenylethylamine alkaloid (79) and one pyrrolidine alkaloid (80).…”

Section: Alkaloidsmentioning

confidence: 99%

“…In addition, the extract treatment significantly reversed the histomorphological changes in the lung, such as loss of alveolar septum, inflammatory infiltration, and fibrosis in diabetes mellitus rats. [67] The effect of the alcoholic fraction of C. sympodialis leaves and its isolated alkaloid, warifteine (8) on anxiety and asthma-like symptoms induced by ovalbumin in mice with allergic airway disease was evaluated. Treatment with plant extract and warifteine improved anxiety-like symptoms and respiratory rate very similar to diazepam in Table 6.…”

Section: Bronchodilator Activitymentioning

confidence: 99%

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Phytochemical Constituents and Biological Activities of Plants from the GenusCissampelos

Yan

et al. 2021

Chemistry & Biodiversity

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Cissampelos is a significant genus comprising of approximately 21 species of the medicinal plants (Menispermaceae). The plants of this genus are used in traditional medicine for the treatment of various ailments such as asthma, arthritis, dysentery, hyperglycemia, cardiopathy, hypertension and other related problems. These plants are rich in bioactive dibenzylisoquinoline and aborphine as well as small amounts of other ingredients. In recent years, the chemical constituents and pharmacological activities of Cissampelos genus have been paid more and more attention due to their diversity. Herein, we compile the chemical constituents and biological activities on this genus, and summarize the 13C‐NMR data of the main bioactive ingredients. All information comes from scientific databases such as Google Scholar, PubMed, Sci‐Finder, ScienceDirect, Web of Science and CNKI. It provides valuable data for the future research and development of Cissampelos genus.

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Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat

Rahman

Ibrahim

Siddiqui

et al. 2022

Braz. J. Pharm. Sci.

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Rumex vesicarius hasbeen extensively used for the management of diabetes in the traditional system of medicine. The current study was designed to investigate antidiabetic and antihyperlipidemic effects of R.vesicarius and also to explore metabolomic profiling using UPLC-QTOF-MS. The effect of extracts was observed by checking the biochemical and histopathological parameters in diabetic rats. The results had shown a significant dosedependent inhibition potential of aqueous extract of R. vesicarius seed against α-amylase and α-glucosidase along with significant inhibition in DPPH free-radical scavenging activity. Oral administration of R. vesicarius to diabetic rats significantly (p< 0.05) ameliorated blood glucose level. It also improved the function of the liver and kidney as well as ameliorated dyslipidemia in diabetic rats. Histopathological examination of the treatment groups reversed the damage of the pancreas, liver, and kidney tissues confirming the antidiabetic efficacy of R. vesicarius. UPLC-QTOF-MS analysis of the extract revealed a total of 42 bioactive compounds, which might contribute to the antidiabetic activity. Based on our findings, we can conclude that R. vesicarius might be a promising candidate for the management of diabetes.

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Ethanol extract of Cissampelos sympodialis ameliorates lung tissue damage in streptozotocin-induced diabetic rats

Cited by 5 publications

References 44 publications

Steviol Glycosides Supplementation Affects Lipid Metabolism in High-Fat Fed STZ-Induced Diabetic Rats

Steviol Glycosides Supplementation Affects Lipid Metabolism in High-Fat Fed STZ-Induced Diabetic Rats

Phytochemical Constituents and Biological Activities of Plants from the GenusCissampelos

Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat

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