The role of selenium in insulin resistance

Fontenelle, Larissa Cristina; Feitosa, Mayara Monte; Morais, Jennifer Beatriz Silva; Silva, Juliana; Freitas, Taynáh Emannuelle Coelho de; Beserra, Jéssica Batista; Henriques, Gilberto Simeone; Marreiro, Dilina do Nascimento

doi:10.1590/s2175-97902018000100139

Cited by 40 publications

(28 citation statements)

References 50 publications

(79 reference statements)

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“…The concentrations of SS and SM were chosen from preliminary experiments considering maximum glutathione peroxidase 1 (GPx1) induction (20)(21)(22)(23)(24)(25). They were in the same ranges that were applied previously for several other cell types.…”

Section: Cell Culture and Treatmentmentioning

confidence: 99%

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Antioxidants and selenocompounds inhibit 3,5-dimethylaminophenol toxicity to human urothelial cells

Erkekoğlu

Chao

Tseng

et al. 2019

Archives of Industrial Hygiene and Toxicology

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Exposure to alkyl anilines may lead to bladder cancer, which is the second most frequent cancer of the urogenital tract. 3,5-dimethylaniline is highly used in industry. Studies on its primary metabolite 3,5-dimethylaminophenol (3,5-DMAP) showed that this compound causes oxidative stress, changes antioxidant enzyme activities, and leads to death of different mammalian cells. However, there is no in vitro study to show the direct effects of 3,5-DMAP on human bladder and urothelial cells. Selenocompounds are suggested to decrease oxidative stress caused by some chemicals, and selenium supplementation was shown to reduce the risk of bladder cancer. The main aim of this study was to investigate whether selenocompounds organic selenomethionine (SM, 10 µmol/L) or inorganic sodium selenite (SS, 30 nmol/L) could reduce oxidative stress, DNA damage, and apoptosis in UROtsa cells exposed to 3,5-DMAP. 3,5-DMAP caused a dose-dependent increase in intracellular generation of reactive oxygen species, and its dose of 50 µmol/L caused lipid peroxidation, protein oxidation, and changes in antioxidant enzyme activities in different cellular fractions. The comet assay also showed single-strand DNA breaks induced by the 3,5-DMAP dose of 50 µmol/L, but no changes in double-strand DNA breaks. Apoptosis was also triggered. Both selenocompounds provided partial protection against the cellular toxicity of 3,5-DMAP. Low selenium status along with exposure to alkyl anilines can be a major factor in the development of bladder cancer. More mechanistic studies are needed to specify the role of selenium in bladder cancer.

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Section: Cell Culture and Treatmentmentioning

confidence: 99%

“…Erkekoglu P, et al Antioxidants and selenocompounds inhibit 3,5-dimethylaminophenol toxicity to human urothelial cells Arh Hig Rada Toksikol 2019;70:[18][19][20][21][22][23][24][25][26][27][28][29] …”

mentioning

confidence: 99%

Antioxidants and selenocompounds inhibit 3,5-dimethylaminophenol toxicity to human urothelial cells

Erkekoğlu

Chao

Tseng

et al. 2019

Archives of Industrial Hygiene and Toxicology

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“…İnsülin direnci üzerine selenyumun etkisi için önerilen mekanizmalar Şekil 5'te görülmektedir. 86 Selenyumun insülin direnci üzerine etkisi için üç mekanizma önerilmektedir.…”

Section: Selenyum Ve Di̇abetes Melli̇tusunclassified

“…Üçüncü olarak, periferik organlarda selenyum, antioksidan etkisinden dolayı insülin duyarlılığını artırmaktadır (Şekil 5C). 86 Rayman ve ark. tarafından, 500 yaşlı katılımcının olduğu çift kör plasebo kontrollü randomize Murat GÜRBÜZ ve ark.…”

Section: Selenyum Ve Di̇abetes Melli̇tusunclassified

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Minerals and Diabetes Mellitus

Gülbaran¹,

Çelik²

2019

Turkiye Klinikleri J Intern Med

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gibi birtakım minerallerin dolaşımdaki seviyeleri diyabet için önemli bir prediktör olabilmekte ve suplementasyonları diyabetik bireylerin sağlık durumlarında yararlı etkiler oluşturabilmektedir. Glukoz homeostazı pankreasın beta hücrelerinden salgılanan insülin hormonunun kontrolü ve koordinasyonu ile sağlanmaktadır. Vücuttaki insülinin üretilememesi veya kullanılamaması durumunda kan glukoz homeostazında bozulmalar meydana gelmekte ve vücuttan bazı minerallerin aşırı atılımı gerçekleşebilmektedir. Aşırı atılım ile gereksinimin artması sonucu glukoz metabolizma yolağında, beta hücre fonksiyonunda ve insülin sinyalizasyon kaskadında bozulmalar meydana gelebilmekte ve bu durum diyabet ve komplikasyonlarının patogenezine katkı sağlayabilmektedir. Bu çalışmada, bazı minerallerin vücuttaki seviyelerinin ve yapılan süplementasyonların diyabet ile ilişkisinin değerlendirilmesi amaçlanmıştır. Bu noktada, odaklandığımız mineraller; çinko, bakır, krom, magnezyum, mangan, bakır, demir, selenyum ve vanadyumdur. Yapılan çalışmalardan elde edilen sonuçlar, vücut mineral düzeyinin diyabet ile ilişkisinde bazı farklılıklar ortaya koymaktadır. Ayrıca, diyabetin önlenmesi veya yönetiminde mineral süplementasyonunun yeterli kanıtlar sağlayamadığını göstermektedir. Diyabet ve komplikasyonları açısından risk altında olan bireylerde dolaşımdaki mineral düzeyinin ve mineral süplementasyonun gerekliliğinin saptanması oldukça önemlidir ve bu noktada daha büyük örnekli ve daha uzun süreli takip gerektiren çalışmalarla desteklenen kanıtlara gereksinim duyulmaktadır.A An na ah ht ta ar r K Ke el li im me el le er r: : Mineraller; diabetes mellitus; kan glukozu A AB BS ST TR RA AC CT T Minerals take an important role in electrolyte balance, preservation and maintenance of bone tissue, blood clotting, and regulation of nerve conduction as well as role as enzyme cofactor in various physiological reactions in metabolism. Circulating levels of a number of minerals, such as zinc, chromium, magnesium, manganese, selenium, may be an important predictor for diabetes, and their supplementation may have beneficial effects on the health status of diabetic individuals. Glucose homeostasis is provided by the control and coordination of insulin hormone secreted from beta cells of the pancreas. In the event that the insulin in the body cannot be produced or used, disruption of blood glucose homeostasis occurs and excessive excretion of some minerals from the body may occur. As a result of increased requirement with excessive excretion, in the glucose metabolism pathway, in beta-cell function and insulin signaling cascade may occur impairments and this occasion may contribute to the pathogenesis of diabetes and its complications. The aim of this review evaluate the relationship between levels and/or supplement of minerals and diabetes mellitus. At this point we focus on zinc, copper, chromium, magnesium, manganese, copper, iron, selenium and vanadium. The results obtained from the studies show some differences in the relationship of body mineral level and ...

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