Acute hypotensive and diuretic activities of Berberis vulgaris root bark aqueous extract in normal rats

Abstract

The aim of this study is to investigate the effectiveness of intravenous administration of Berberis vulgaris root bark aqueous extract (BRBD) on the cardiovascular and renal functions of healthy normotensive rats. The different doses of BRBD 1, 10 and 20 mg/kg were administered intravenously (i.v) in normal rats. Blood pressure, diuretic activity and serum renal profile were analyzed. Intravenous injection of BRBD at the different doses of 1, 10 and 20 mg/kg showed a dose-dependent reduction in mean arterial blood pressure (P<0.001). At different doses of 1, 10 and 20 mg/kg, the hypotensive effect remained for more than one hour. Single dose administration of BRBD at doses of 10 and 20 mg/kg caused a significant increase in urine output (P<0.001) as compared to the control rats. Serum renal profile test (albumin, Urea, Uric Acid, creatinine and BUN) did not show any significant alteration. The authors conclude that the BRBD is a potent hypotensive and possesses diuretic potential

Phytochemistry and pharmacological activity of the genus artemisia

“…Aqueous methanolic extracts were given at a dose of (300, 400, and 500 mg/kg) by gavage process excellent results for the systolic blood pressure of normotensive rats observed at 400 mg/kg afterward 20 min consummation while others don’t influence diastolic BP or HR compared with enalapril (30 mg/kg). Oral consummation of AP extracts next 20 min systolic BP in normotensive hypertensive rats, on the contrary, the aqueous extract of AP extenuated the BP of hypertensive rats much faster as that of enalapril (Ghisalberti et al 1998 ; Esmaeili et al 2009 ; Ahmed et al 2017 ). Another variety of the genus artemisia that is A. pallens has successfully been reported in Ayurveda for the treatment of high blood pressure (Pavithra et al 2018 ).…”

Plants With Antihypertensive Activities: A Review

“…Berberis vulgaris is a plant that is widely used in traditional medicine 17 . Aqueous extract of Berberis vulgaris root bark was proven to have antihypertensive activity tested on Rats.…”