2017
DOI: 10.1590/s2175-97902017000300173
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Abstract: The limitations in absorption of drugs with narrow absorption window, or those unstable in the intestinal pH or those exhibiting low solubility at high pH are primary candidates for gastroretentive drug delivery systems (GRDDS). The delivery system has been widely explored for its commercial potential for a wide variety of therapeutic agents. GRDDS offer clinical therapeutics for acute and chronic management. Hypertension is a chronic disease that requires long term treatment and its management by patient comp… Show more

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Cited by 19 publications
(15 citation statements)
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“…The empty stomach performs rhythmic peristaltic contractions known as hunger contractions. The regulation of gastric emptying is by neural and hormonal reflexes like vagal tone and mottling which increase the gastric motility 3,4 .…”
Section: Gastric Emptying Ratementioning
confidence: 99%
See 2 more Smart Citations
“…The empty stomach performs rhythmic peristaltic contractions known as hunger contractions. The regulation of gastric emptying is by neural and hormonal reflexes like vagal tone and mottling which increase the gastric motility 3,4 .…”
Section: Gastric Emptying Ratementioning
confidence: 99%
“…Delivery System (GRDDS): 4 Various factors which affect gastric retention time (GRT) that influence on the development of gastro-retentive dosage forms and prolong the dosing intervals and thus improve patient compliance, these factors can be classified into:…”
Section: Factors Controlling Gastro Retentive Drugmentioning
confidence: 99%
See 1 more Smart Citation
“…[170] CODEN (USA): JDDTAO solubility that are less soluble in a high pH environment 2 . Also prolonged gastric retention time (GRT) in the stomach could be advantageous for local action in the upper part of the small intestine e.g.…”
Section: Issn: 2250-1177mentioning
confidence: 99%
“…Various categories of drug have been encapsulated such as non-steroidal anti-inflammatory drugs, enzymes, peptides/proteins, and acid labile drugs 4 .…”
Section: Introductionmentioning
confidence: 99%