2017
DOI: 10.1590/s2175-97902017000300163
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Analytical results are widely used to assess batch-by-batch conformity, pharmaceutical equivalence, as well as in the development of drug products. Despite this, few papers describing the measurement uncertainty estimation associated with these results were found in the literature. Here, we described a simple procedure used for estimating measurement uncertainty associated with the dissolution test of acetaminophen tablets. A fractionate factorial design was used to define a mathematical model that explains th… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
3
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 12 publications
(3 citation statements)
references
References 32 publications
0
3
0
Order By: Relevance
“…Tetrabutyl ammonium hydroxide concentration, buffer pH and organic phase concentration Capacity factor of eberconazole nitrate (reverse phase HPLC method) (Krishna et al, 2016) Central composite design Cyclodextrin concentration, pH, and voltage Resolution between peaks and analysis time of a clycodextrin-modified micellar electrokinetic chromatography (Orlandini et al, 2016) Box-Behnken design Acetonitrile content in mobile phase, ammonium acetate concentration in the aqueous phase, and pH of aqueous phase Retention factor of impurity and selectivity of critical peal pair in bilastine and its degradation impurities determination by liquid chromatographic method (Terzic et al, 2016) Placket-Burman design Temperature, pH, buffer concentration, and L-asparaginase concentration Absorvance at 450 nm, usedfor L-asparaginase activity method (Yao et al, 2016) Fractionate factorial design Time of dissolution, volume of dissolution media, pH of dissolution media, and rotation speed Amount of acetaminophen dissolved during (Romero, Lourenço, 2017) as recent examples of the utilization of DoE in the development and optimization of analytical methods. DoE tools help to identify and explain how critical analytical parameters (CAPs) (independent variables) affects the analytical method performance characteristics (AMPC) (dependent variables) and, therefore, the analytical target profile (ATP).…”
Section: Applications Of Design Of Experiments In Qbd and Aqbdmentioning
confidence: 99%
“…Tetrabutyl ammonium hydroxide concentration, buffer pH and organic phase concentration Capacity factor of eberconazole nitrate (reverse phase HPLC method) (Krishna et al, 2016) Central composite design Cyclodextrin concentration, pH, and voltage Resolution between peaks and analysis time of a clycodextrin-modified micellar electrokinetic chromatography (Orlandini et al, 2016) Box-Behnken design Acetonitrile content in mobile phase, ammonium acetate concentration in the aqueous phase, and pH of aqueous phase Retention factor of impurity and selectivity of critical peal pair in bilastine and its degradation impurities determination by liquid chromatographic method (Terzic et al, 2016) Placket-Burman design Temperature, pH, buffer concentration, and L-asparaginase concentration Absorvance at 450 nm, usedfor L-asparaginase activity method (Yao et al, 2016) Fractionate factorial design Time of dissolution, volume of dissolution media, pH of dissolution media, and rotation speed Amount of acetaminophen dissolved during (Romero, Lourenço, 2017) as recent examples of the utilization of DoE in the development and optimization of analytical methods. DoE tools help to identify and explain how critical analytical parameters (CAPs) (independent variables) affects the analytical method performance characteristics (AMPC) (dependent variables) and, therefore, the analytical target profile (ATP).…”
Section: Applications Of Design Of Experiments In Qbd and Aqbdmentioning
confidence: 99%
“…The rank order of the negative sign means antagonistic effects on the studied response. This equation stated that the variables have lesser impact on disintegration time [21,22] . The relationship between independent and dependent variables on disintegration time was studied by plotting the 3D response surface graphs (fig.…”
Section: Resultsmentioning
confidence: 99%
“…According to the study of D.C.Romero et al [21]. The rotation speed is a critical parameter of dissolution; its effect is very significant.…”
Section: Rotation Speedmentioning
confidence: 99%