Hydrocortisone release from tablets based on bioresorbable poly(ether-ester-urethane)s

Abstract

Bioresorbable linear poly(ether-ester-urethane)s with different hydrophilic characteristics were synthesized from triblock copolymers of poly(ε-caprolactone)-poly(ethylene oxide)-poly(ε-caprolactone) (PCL-PEO) as macrodiols, and L-lysine diisocyanate (LDI) or hexamethylenediisocyanate (HDI) were used as the required diisocyanates. Macrodiols were obtained by ring-opening polymerization (ROP) of ε-caprolactone (CL). Polyurethanes were synthesized by the reaction of the triblock copolymers with LDI or HDI in solution using stannous 2-ethylhexanoate as catalyst. Polyurethane tablets were fabricated and investigated as prospective drug delivery systems. The effect of the PEO content on the polymers' performance as drug carriers was evaluated. It was found that water provoked more swelling and erosion of polymers with higher contents of PEO. The hydrocortisone release profiles were analyzed using the Ritger-Peppas approximation. An anomalous release behaviour (values of n higher than 0.5) was found for most of the analyzed samples.

Biocompatible PEO-b-PCL Nanosized Micelles as Drug Carriers: Structure and Drug–Polymer Interactions

“…The biocompatible PEO serves as the hydrophilic shell providing stealth properties to the micellar system, preventing its uptake by the reticuloendothelial system (RES) [ 15 ]. To date, several studies have reported the development of PEO-b-PCL polymeric micelles as effective vehicles for the solubilization and delivery of doxorubicin [ 16 ], paclitaxel [ 17 ], curcumin [ 18 , 19 ], indomethacin [ 20 ], camptothecin [ 21 ], tacrolimus [ 22 ], cyclosporine [ 23 ], amiodarone [ 24 ], hydrocortisone [ 25 ], clotrimazole [ 15 ], cucurbitacin [ 26 ], among others.…”

Enhanced Skin Permeation of Hydrocortisone Using Nanoemulsion as Potential Vehicle

“…Several approaches including chitosan nanoparticles, liposomal gels, nanoemulsions, positively charged nanoemulsions, microemulsions and cyclodextrin solutions were studied successfully for dermal and transdermal drug delivery of HCN. Some polymer‐based tablets and colon targeted tablets have also been investigated for the oral drug delivery of HCN . Recently, the spray dried solid dispersions have also been studied for the oral bioavailability enhancement of HCN .…”

Waterborne poly(urethane-urea)s films as a sustained release system for ketoconazole

“…PEO segments improved biocompatibility and increased drug release in vitro (12). The main release mechanisms of the tablets involved the swelling of the polymer, when in contact with aqueous medium, due to the high hydrophilicity of PEO segments, followed by partial diffusion of the drug through the swollen matrix, and finally, polymer erosion and drug release (2).…”

“…Polyurethanes (PU) compose a very versatile class of materials, possibly being tailor-made with biocompatible characteristics to biological systems, such as blood, organs and organic tissues and biodegradability (1)(2)(3). The properties of those systems differ greatly depending on the composition and stoichiometry of monomers (4,5).…”

“…Studies reported the solubilization and release of drugs using some amphiphilic di-and triblock copolymers of PEO-PPO (8) and PEO-PPO-PEO (9,10), respectively. Lately, matrices of PU based on PEO, produced in organic solvent media, have been applied for the manufacture of oral dosage tablets containing high drug loads (2,11,12). PEO segments improved biocompatibility and increased drug release in vitro (12).…”