Morphological and molecular analysis of apoptosis in the corpus cavernosum of rats submitted to a chronic alcoholism model

Meirelles, Rogério José de Azevedo; Neto, Fermino Sanches Lizarte; Cirino, Múcio Luiz de Assis; Novais, Paulo Cézar; Gula, Isabella Stracieri; Silva, Jairo Pinheiro da; Tazzima, Maria de Fátima Galli Sorita; Fazan, Valéria Paula Sassoli; Durand, M; Tirapelli, Daniela Pretti da Cunha; Carvalho, C.; Schimming, Bruno César; Molina, C.; Tucci, Sílvio; Tirapelli, Luís Fernando

doi:10.1590/s0102-865020200030000005

Cited by 2 publications

(5 citation statements)

References 27 publications

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“…The increase in caspase-3 was also reported in an experimental study in rats submitted to a chronic alcohol model. These animals presented also a significant decrease in the smooth muscle area of the corpus cavernosum 14 . These authors claimed that alcoholism could affect the integrity of the smooth muscle and endothelial cells of the corpus cavernosum, and this could be important in the ED 14 .…”

Section: ■ Discussionmentioning

confidence: 77%

“…Ethanol has several effects on male sexual activity 12 . Previous studies from our group have demonstrated that chronic alcoholism induced dysfunction of smooth muscle in the corpus cavernosum of rats 13 and decreased cavernosal smooth muscle area in rats 14 .…”

Section: Introductionmentioning

confidence: 73%

“…Differentially expressed microRNAs in the corpus cavernosum of diabetic and ED rats play potential roles in the regulation of genes that are associated with the processes of apoptosis, fibrosis, vascular smooth muscle contraction, among others, mainly influencing the functions of the endothelium and smooth muscle in the corpus cavernosum 18 , although no alteration in miRNA-21 gene expression was observed in rats submitted to a chronic alcohol model 14 .…”

Section: ■ Discussionmentioning

confidence: 99%

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Chronic alcoholism associated with diabetes induced apoptosis in the corpus cavernosum of rats

Schimming

Cirino

Neto³

et al. 2020

Acta Cir. Bras.

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Section: ■ Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 73%

Section: ■ Discussionmentioning

confidence: 99%

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Chronic alcoholism associated with diabetes induced apoptosis in the corpus cavernosum of rats

Schimming

Cirino

Neto³

et al. 2020

Acta Cir. Bras.

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“…The link between alcohol consumption and erectile dysfunction (ED) has been studied for years (165)(166)(167)(168)(169)(170). The corpus cavernosum (CC) of the vas deferens are cavernous spaces which fill with blood to facilitate tumescence.…”

Section: Vas Deferensmentioning

confidence: 99%

“…The corpus cavernosum (CC) of the vas deferens are cavernous spaces which fill with blood to facilitate tumescence. In addition to the constriction of penile arteries, this increase in intracorporeal pressure is also dependent on the relaxation of non-vascular smooth muscle cells ( 169 , 170 ). The chronic exposure of rats to ethanol (5–20% in diet) caused morphological changes in the smooth muscle myocytes, such as a decreased number of elastic fibers and collagen type 4 ( 170 ), and decreased smooth muscle area along with increased expression of Caspase 3 therefore increased apoptosis ( 169 ).…”

Section: Muscle Types and Their Mechanisms For Contractionmentioning

confidence: 99%

Alcohol Use Disorders and Their Harmful Effects on the Contractility of Skeletal, Cardiac and Smooth Muscles

Alleyne¹,

Dopico²

2021

Adv. Drug Alcohol Res.

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Alcohol misuse has deleterious effects on personal health, family, societal units, and global economies. Moreover, alcohol misuse usually leads to several diseases and conditions, including alcoholism, which is a chronic condition and a form of addiction. Alcohol misuse, whether as acute intoxication or alcoholism, adversely affects skeletal, cardiac and/or smooth muscle contraction. Ethanol (ethyl alcohol) is the main effector of alcohol-induced dysregulation of muscle contractility, regardless of alcoholic beverage type or the ethanol metabolite (with acetaldehyde being a notable exception). Ethanol, however, is a simple and “promiscuous” ligand that affects many targets to mediate a single biological effect. In this review, we firstly summarize the processes of excitation-contraction coupling and calcium homeostasis which are critical for the regulation of contractility in all muscle types. Secondly, we present the effects of acute and chronic alcohol exposure on the contractility of skeletal, cardiac, and vascular/ nonvascular smooth muscles. Distinctions are made between in vivo and in vitro experiments, intoxicating vs. sub-intoxicating ethanol levels, and human subjects vs. animal models. The differential effects of alcohol on biological sexes are also examined. Lastly, we show that alcohol-mediated disruption of muscle contractility, involves a wide variety of molecular players, including contractile proteins, their regulatory factors, membrane ion channels and pumps, and several signaling molecules. Clear identification of these molecular players constitutes a first step for a rationale design of pharmacotherapeutics to prevent, ameliorate and/or reverse the negative effects of alcohol on muscle contractility.

show abstract

Morphological and molecular analysis of apoptosis in the corpus cavernosum of rats submitted to a chronic alcoholism model

Cited by 2 publications

References 27 publications

Chronic alcoholism associated with diabetes induced apoptosis in the corpus cavernosum of rats

Chronic alcoholism associated with diabetes induced apoptosis in the corpus cavernosum of rats

Alcohol Use Disorders and Their Harmful Effects on the Contractility of Skeletal, Cardiac and Smooth Muscles

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