Comparative study of peritoneal adhesions after intraperitoneal implantation in rats of meshes of polypropylene versus polypropylene/polyglecaprone versus polyester/porcine collagen

Ribeiro, Waston Gonçalves; Rodrigues, Diego Vinnicyus Santos; Atta, Francisco Felipe Moreira; Ramos, Izabelle Smith Frazão; Frazão, Fabiola Nassar Sousa; Torres, Orlando Jorge Martins; Pitombo, Marcos Bettini

doi:10.1590/s0102-865020190060000003

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…Its primary purpose is to minimize the appearance of adhesions between intra-abdominal structures and the visceral surface of the mesh. However, this layer must not delay or negatively affect the neoperitonization process of its surface 14 . Secondarily, this interface, mediated by the tissue separating barriers, should compromise neither the inflammation nor the fibroplasia process responsible for the incorporation of the macroporous parietal face of the mesh 15 - 18 .…”

Section: Introductionmentioning

confidence: 99%

Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes

et al. 2021

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Purpose To compare tissue inflammatory response, foreign body reaction, fibroplasia, and proportion of type I/III collagen between closure of abdominal wall aponeurosis using polyglactin suture and intraperitoneal implant of polypropylene, polypropylene/polyglecaprone, and polyester/porcine collagen meshes to repair defects in the abdominal wall of rats. Methods Forty Wistar rats were placed in four groups, ten animals each, for the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone, and polyester/porcine collagen meshes or suture with polyglactin (sham) after creation of defect in the abdominal wall. Twenty-one days later, histological analysis was performed after staining with hematoxylin-eosin and picrosirius red. Results The groups with meshes had a higher inflammation score (p < 0.05) and higher number of gigantocytes (p < 0.05) than the sham group, which had a better fibroplasia with a higher proportion of type I/III collagen than the tissue separating meshes (p < 0.05). There were no statistically significant differences between the three groups with meshes. Conclusions The intraperitoneal implant of polypropylene/polyglecaprone and polyester/porcine collagen meshes determined a more intense tissue inflammatory response with exuberant foreign body reaction, immature fibroplasia and low tissue proportion of type I/III collagen compared to suture with polyglactin of abdominal aponeurosis. However, there were no significant differences in relation to the polypropylene mesh group.

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Section: Introductionmentioning

confidence: 99%

Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes

et al. 2021

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Synthetic Polymers

Skoglund,

Roy,

Cavender

2023

Patty's Toxicology

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The global annual production of plastic is approaching a half‐billion tonnes and two families of synthetic polymers, polyethylene and polypropylene, account for approximately 45% of this production. The most common applications for synthetic polymers are in packaging and consumer/household goods and they are often referred to as single‐use plastics. However, other applications for synthetic polymers include medical/medical device, construction, agriculture, automotive, and industrial uses. Exposure to monomers, polymers, resins, and plastics can occur during the initial polymerization and manufacturing of the resins, the subsequent polymerization and manufacturing of the plastics and finished products, during use of the finished product, and during the product's end‐of‐life stage. This chapter focuses on understanding and mediating the toxicological issues with synthetic polymers in the workplace, including the production of the polymers, the resins, and the finished plastic products. In addition to the toxicology profiles, this chapter discusses production and uses, potential exposures, hazard classification, thermo‐decomposition products, sensitive applications such as food‐contact and medical applications, and exposure guidelines. The environmental impact of these synthetic polymers can be significant, so this chapter also touches on the life cycle of these polymers including recycled and bio‐based feedstocks, carbon emissions, macroplastic and microplastic pollution, degradation in the environment, additives, and end‐of‐life scenarios.

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Modern aspects of allohernioplasty of postoperative ventral hernias (a literature review)

Vorovskyі¹

2021

ZMJ

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The aim. Based on the data of the publications of herniologists for the last 5 years to examine the effectiveness and safety of prosthetic materials used in hernioplasty of postoperative ventral hernias. According to surgeons, the incidence of postoperative ventral hernia is up to 20 % of performed laparotomies, and if risk factors are present – up to 70 %. This problem was considered solved by the use of prosthetic mesh that became the standard of surgical approach in hernia repair since a recurrence rate was reduced to 20 %. However, the results of histological examination and body biological responses to an implant showed chronic inflammatory processes due to use of prosthetic material, especially polypropylene, causing purulent-inflammatory complications and intraperitoneal adhesion in 20.0–45.8 %. To prevent adhesion, a special barrier layer was applied on the polypropylene mesh, a process of mesothelial epithelialization (formation of the neoperitoneum) was supposed to occur, thereby reducing the risk of adhesions. A temporary nature of the barrier coating, where adhesion may develop at any time after implantation resulting in complications, has proven to be a potential problem of composite prostheses. There has been an attempt to address the challenge by using biological meshes made of decellularised pig and bovine dermis. However, recurrence rates after repair of hernia using the biological meshes was 6.3–61.0 %, wound infection – 16.0 %. Conclusions. Thus, world publications have proved today that it is impossible to perform adequate hernioplasty of postoperative hernias without the use of prosthetic material. However, complications and recurrences of the disease remain quite high. In order to improve these indicators, a sufficient number of studies were conducted, the effect of various prosthetic meshes on the patient body and on the postoperative wound itself was examined. Nevertheless, all the results are often contradictory, without specific conclusions about the indications for the use of method and type of prosthetic material.

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Comparative study of peritoneal adhesions after intraperitoneal implantation in rats of meshes of polypropylene versus polypropylene/polyglecaprone versus polyester/porcine collagen

Cited by 3 publications

References 29 publications

Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes

Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes

Synthetic Polymers

Modern aspects of allohernioplasty of postoperative ventral hernias (a literature review)

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