2019
DOI: 10.1590/s0102-865020190050000004
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Abstract: Purpose: To establish a new rat model, the pathogenesis of which is closer to the clinical occurrence of chronic obstructive jaundice with liver fibrosis. Methods: 90 SD rats were randomly divided into 3 groups. Group A common bile duct ligation, group B common bile duct injection compont and group C injection saline. The serum of three groups was extracted, and the liver function was detected by ELISA. HE staining, Masson staining and immunohistochemistry were used to … Show more

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Cited by 7 publications
(3 citation statements)
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“…In the biochemical findings of patients with OJ, AST, ALT, ALP, GGT and bilirubin values increase due to the toxic effect of cholestasis 8 . There are elevated biochemical AST, ALT, ALP and GGT values in NASH disease, which is associated with a fatty liver, inflammation, hepatocyte swelling, and fibrosis.…”
Section: Discussionmentioning
confidence: 98%
“…In the biochemical findings of patients with OJ, AST, ALT, ALP, GGT and bilirubin values increase due to the toxic effect of cholestasis 8 . There are elevated biochemical AST, ALT, ALP and GGT values in NASH disease, which is associated with a fatty liver, inflammation, hepatocyte swelling, and fibrosis.…”
Section: Discussionmentioning
confidence: 98%
“…При билиарной декомпрессии имеет место механическое сдавливание междольковых артерий, вен и лимфатических сосудов расширенными желчными протоками и окклюзия русла капилляров [2,18]. При полной обтурации билиарного дерева происходит расширение всей системы желчевыводящих протоков, образование тромбов, набухание выстилки синусоидов, пролиферация эпителия ворсинок желчных протоков, что приводит к развитию оксидативного стресса и деструкции эндотелия сосудов с последующим развитием ишемии -реперфузионного синдрома [4, 21,37,38]. А реперфузионный синдром, в свою очередь, выступает фактором развития печеночной недостаточности после восстановления проходимости желчных протоков [7,26].…”
Section: Introductionunclassified
“…To date, most hyperbilirubinemia or jaundice models are established using adult mice or rats [12–14] . The Gunn rat lacking UGT1A1 can be used to model neonatal hyperbilirubinemia by injection of sulfadimethoxine (Sulfa) or phenylhydrazine (PHZ) [15] .…”
Section: Introductionmentioning
confidence: 99%