Ointment of Ximenes americana promotes acceleration of wound healing in rats

Abstract

Purpose To evaluate the healing potential of the Ximenia americana hydroalcoholic extract in 10% cream in excisional wound models in rats. Methods Sixty male adults Wistar rats were submitted to skin and subcutaneous tissue surgery in the right and left thoracic regions, divided into three experimental groups: Standard submitted to treatment with only the base vehicle, Treated wounds treated with hydroalcoholic extract of X. americana applied on 10%, Lanette base and Control, untreated wounds. The treatment was performed daily and the wounds evaluated microscopically by the quantification of fibroblasts, collagen fibers and blood vessels. Results The histomorphometric analysis showed a significant increase in the number of fibroblasts, collagen fibers and blood vessels in the treated group. Conclusion The topical action of the cream based on Ximenia americana shows angiogenic effects and improves the replacement of collagen, suggesting its use for the development of herbal remedy in the treatment of cutaneous wound healing.

Effects of the healing activity of rosemary-of-Chapada (Lippia gracilis Schauer) on cutaneous lesions in rats

“…In this study, the effects of essential oil from leaves of L. gracilis Schauer during the healing of rat skin lesions were investigated, whereby inflammation, angiogenesis, extracellular matrix formation, and wound contraction were evaluated. The proposed experimental model has been used to study the biological mechanisms involved in the healing of skin wounds 2,6,[22][23][24][25] . An ointment containing 10% of essential oil was prepared, used topically on wounds for 21 consecutive days and tested for healing potential.…”

Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats

“…These observations may explain the data obtained in this study with the increase in collagen in samples treated only with topical application of S. dendroideum, which also has flavonoids in its composition 16 . Other herbal medicines promote increased collagen in skin and tendon healing [34][35][36][37] which represents one of the most important factors for the tecidual repair after the lesion 38 .…”