2019
DOI: 10.1590/s0102-865020190030000005
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Abstract: Purpose To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG). Methods The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 m… Show more

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Cited by 9 publications
(5 citation statements)
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“…The preferential killing ability of extracts from other Usnea species were also reported from animal model study. For example, ethyl acetate extract of U. longissima exhibits antitumor effect against N -methyl- N ’-nitro- N -nitrosoguanidin (MNNG) induced on esophagogastric tumor in rats and it is nontoxic to high doses up to 2000 mg/kg [ 34 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The preferential killing ability of extracts from other Usnea species were also reported from animal model study. For example, ethyl acetate extract of U. longissima exhibits antitumor effect against N -methyl- N ’-nitro- N -nitrosoguanidin (MNNG) induced on esophagogastric tumor in rats and it is nontoxic to high doses up to 2000 mg/kg [ 34 ].…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the drug-induced exogenous oxidative stress may induce preferential killing to cancer cells but show low toxicity to normal cells [ 36 ]. Therefore, the antioxidant in several Usnea species may play a role in preferential killing to several types of cancer cells [ 12 , 34 ].…”
Section: Discussionmentioning
confidence: 99%
“…U. longissima extract demonstrated prominent anticancer effect and selectivity to cancer tissue in animals at concentrations of 50 and 100 mg/kg without any toxic effects. This extract did not reveal any lethal effect even when administered in high concentrations (500, 1000, and 2000 mg/kg) [118].…”
Section: Anticancer Effects Of Lichens In Animal Modelsmentioning
confidence: 76%
“…Therefore, nitrites are the active ingredient and nitrates serve as reservoirs that supply nitrites. There are numerous epidemiological studies that associate the potential risk of gastric cancer and other cancers with the intake of nitrates, nitrites and nitrosamines in the diet 15 , 17 , 19 - 21 .…”
Section: Discussionmentioning
confidence: 99%