2018
DOI: 10.1590/s0102-865020180100000003
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Abstract: Purpose:To investigate the role of the exogenous supply of adenosine triphosphate (ATP) in the expression of Bax and Bcl2L1 genes in intestinal ischemia and reperfusion (IR) in rats. Methods:The study was designed as a randomized controlled trial with a blinded assessment of the outcome. Eighteen adult male Wistar-EPM1 rats were housed under controlled temperature and light conditions (22-23°C, 12 h light/dark cycle). The animals were randomly divided into 3 groups: 1. Sham group (SG): no clamping of the super… Show more

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Cited by 3 publications
(3 citation statements)
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“…BCL2L1 was determined to be a direct target gene of miR-663b. Bcl2 genes are a mammalian family of genes that encode several proteins that directly regulate the activation of caspase-mediated apoptosis (32). As a member of this family, BCL2L1 acts as an antiapoptotic protein, with decreased expression activating a caspase cascade that ultimately promotes apoptosis.…”
Section: Discussionmentioning
confidence: 99%
“…BCL2L1 was determined to be a direct target gene of miR-663b. Bcl2 genes are a mammalian family of genes that encode several proteins that directly regulate the activation of caspase-mediated apoptosis (32). As a member of this family, BCL2L1 acts as an antiapoptotic protein, with decreased expression activating a caspase cascade that ultimately promotes apoptosis.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, ATP plays a key role in the cascade reaction of ischemia and reperfusion. Once ATP depletion occurs, cell damage in brain can lead to cell death due to necrosis or apoptosis [8,9]. Guan [10] and Zhen [11] et al both pointed out that the decrease of ATP and lacking of nutrient and oxygen are the main cause of cell death and tissue infarction after ischemic stroke.…”
Section: Figurementioning
confidence: 99%
“…As we have known, the brain is a high energy-consuming organ that greatly depends on adenosine triphosphate (ATP), which is responsible for supplying energy to maintain brain function. Once ATP depletion occurs, cell damage in the brain can lead to cell death (Fagundes et al, 2018;Giannone et al, 2012). Hence, it can consequently lead to both neurological deficit and motor dysfunction.…”
Section: Introductionmentioning
confidence: 99%