Protective effects of Polygonatum sibiricum polysaccharide on acute heart failure in rats

Abstract

To investigate the protective effects of Polygonatum sibiricum polysaccharide (PSP) on acute heart failure (AHF) in rats. Methods: Sixty rats were randomly divided into control, model, and low-, middle-and highdose PSP groups, 12 rats in each group. The low-, medium-and high-dose PSP groups were intragastrically administrated with 100, 200 and 400 mg/kg PSP for 5 days, respectively. On the sixth day, the AHF model was established by intraperitoneal injection of adriamycin. After 24h, the cardiac function, serum biochemical indexes, myocardial ATPase and succinate dehydrogenase levels and apoptosis related protein expressions were determined. Results: Compared with model group, in high-dose PSP group the heart rate, left ventricular systolic pressure, ±dp/dt max , serum superoxide dismutase level, myocardial Na +-K +-ATPase, Ca 2+-Mg 2+-ATPase and succinate dehydrogenase levels and myocardial Bcl-2 and Caspase-3 protein expression levels were significantly increased (P<0.05), the left ventricular end diastolic pressure, serum cTnI, CK-MB, TNF-α, IL-6, malondialdehyde and nitric oxide levels and myocardial Bax and cleaved Caspase-3 protein expression levels were significantly decreased (P<0.05). Conclusions: Polysaccharide can prevent the acute heart failure induced by adriamycin. The mechanism may be related to its anti-oxidative stress, anti-inflammation and inhibition of cardiac myocyte apoptosis.

Polygonatum sibiricum polysaccharide alleviates inflammatory cytokines and promotes glucose uptake in high‑glucose‑ and high‑insulin‑induced 3T3‑L1 adipocytes by promoting Nrf2 expression

“…These results suggest that PSP reduces the secretion of inflammatory cytokines which can promote GLUT-4 expression and glucose uptake in ir-3T3-l1 adipocytes and alleviates the ir of 3T3-l1 adipocytes. Similar to the results of the present study that indicated PSP's role in anti-inflammation, previous studies also found that PSP played anti-inflammatory roles via IL-1β, il-6 and TnF-α (11,14). PSP also delayed the progression of diabetic retinopathy and cataracts (15,16), further indicating its therapeutic potential in T2dM.…”

“…Polygonatum sibiricum and PSP have many pharmacological applications and biological activities and has used to treat a number of diseases (9,10). it is reported that PSP could inhibit inflammation such as interleukin (IL)-1β, il-6 and tumor necrosis factor (TnF)-α expression in lipopolysaccharide-treatment raW264.7, ovariectomized rat, acute heart failure rats, suggest that PSP had anti-inflammation effect (12)(13)(14). Moreover, PSP alleviated hyperglycemia and reduced oxidative stress to delay the progression of diabetic retinopathy and cataracts (15,16).…”

Antioxidant Effect of Polygonatum sibiricum Polysaccharides in D-Galactose-Induced Heart Aging Mice

“…With in-depth studies, researchers discovered that PSP exhibits a variety of biological activities, such as antiaging, reducing blood lipids, enhancing immune function, and promoting osteoblastic differentiation [10,17,18]. Recently, it has been reported that PSP administration inhibited acute heart failure and cardiomyocyte death induced by Adriamycin insult, indicating the protection of PSP on the heart [19].…”

aFGF Targeted Mediated by Novel Nanoparticles-Microbubble Complex Combined With Ultrasound-Targeted Microbubble Destruction attenuates Doxorubicin-Induced Heart Failure via Anti-Apoptosis and Promoting Cardiac Angiogenesis

“…The increase of Bcl-2 inhibits apoptosis by interfering with the release of cytochrome C to block the activation of Caspase-3. The increase of Bax promotes cytochrome C to pass through the mitochondrial membrane, activate Caspase-9, and then activate Caspase-3, which leads to apoptosis (Zhu et al, 2018). Cytochrome C-mediated apoptosis plays a key role in cardiomyocyte apoptosis.…”