Hyperbaric oxygenation on adhesions prevention after laparotomy in rats

Bento, Simone Vargas; Nunes, Tarcizo Afonso; Araújo, I.; Silva, Roberto Carlos Oliveira e; Vidigal, Paula Vieira Teixeira; Carvalhais, Ricardo Machado

doi:10.1590/s0102-865020180090000011

Cited by 5 publications

(1 citation statement)

References 30 publications

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“…Because it remains unclear whether the effect of HBO on ASBO in humans is cellular, biochemical, or physical in nature, it is difficult to explain the mechanism of our result. However, some animal experiments have been performed [ 15 – 17 ]. In an experiment on dogs that used intestinal closed loop obstructions, Cross reported that, as barometric pressure increased, the absorption of gas from the closed loop obstructions increased in dogs who were breathing in ambient air (i.e., not breathing in a high concentration of oxygen) [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of barometric pressure on adhesive small bowel obstruction: a retrospective study

et al. 2020

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Background Adhesive small bowel obstruction (ASBO) is one of the most common causes of postoperative morbidity. According to Boyle’s law, decreased barometric pressure expands the volume of intestinal gas. We aimed to elucidate the relationship between barometric pressure and ASBO. Methods We divided 215 admissions of 120 patients with ASBO into three groups: the fasting group, which responded to fasting ( n = 51); the decompression group, which was successfully treated with gastrointestinal decompression ( n = 104); and the surgery group which required emergency or elective surgery to treat ASBO ( n = 60). We compared and examined clinical backgrounds, findings on admission, and barometric pressure during the peri-onset period (29 days: from 14 days before to 14 days after the onset of ASBO). Results There were significant differences among the three groups regarding gender, history of ASBO, hospital length of stay, and barometric pressure on the onset day of ASBO. Barometric pressure on the onset day was significantly higher in the fasting group than in the decompression group ( p = 0.005). During pre-onset day 5 to post-onset day 2, fluctuations in the barometric pressure in the fasting and decompression groups showed reciprocal changes with a symmetrical axis overlapping the median barometric pressure in Matsumoto City; the fluctuations tapered over time after onset. In the fasting group, the barometric pressure on the onset day was significantly higher than that on pre-onset days 14, 11, 7, 4, 3, and 2; post-onset days 3 and 10; and the median pressure in Matsumoto City. Conversely, in the decompression group, the barometric pressure on the onset day was lower than that on pre-onset days 14, 5–2; post-onset days 1, 2, 7, 8, 11, 13, and 14; and the median pressure in Matsumoto City. In the surgery group, the barometric pressure on the onset day was equivalent to those on the other days. Conclusions ASBO with response to conservative treatment is vulnerable to barometric pressure. Additionally, ASBO that is successfully treated with fasting and decompression is associated with a different barometric pressure on the onset day and reciprocal fluctuations in the barometric pressure during the peri-onset period.

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Section: Discussionmentioning

confidence: 99%