Comparative study of fibrosis induced by Marlex®, Parietex Composite®, Vicryl® and Ultrapro® meshes1

Abstract

Purpose: To evaluate the fibrosis induced by four different meshes: Marlex ® , Parietex Composite ® , Vicryl ® and Ultrapro ® . Methods: Histological cutouts of abdominal wall were analyzed with polarized light 28 days after the meshes implants and colorized by picrosirius to identify the intensity of collagen types I and III, and their maturation index. Results: When the four groups were compared, the total collagen area analyzed was bigger in groups A and D, with no difference between them. The collagen type I density was bigger in group A, with an average of 9.62 ± 1.0, and smaller in group C, with an average of 3.86 ± 0.59. The collagen type III density was similar in groups A, B and C, and bigger in group D. The collagen maturation index was different in each of the four groups, bigger in group A with 0.87, group B with 0.66, group D with 0.57 and group C with 0.33 (p = 0.0000). Conclusion:The most prominent fibrosis promotion in the given meshes was found on Marlex ® (polypropylene mesh) and the Parietex Composite ® (non-biodegradable polyester); the collagen maturation index was higher in the Marlex ® mesh, followed by Ultrapro ® , Parietex Composite ® and Vicryl ® meshes.

Histological evaluation of capsules formed by texturized silicone implants with and without polyester mesh coverage (Parietex®). A study on female rats

“…In a recent study with Parietex® mesh, the same chosen for this study, Parietex® mesh was compared to other types of synthetic meshes and presented less intense fibrosis than the ones of polypropylene mesh 30 .…”

Are the collagen types and density in the wound healed after midline and transverse laparotomy different? An experimental study in mice

“…Measurements were semi-quantitative, and the rate of Type I and III collagens were recorded in percentage (%). Collagen I/Collagen III ratio was used to calculate maturation index [17].…”