Intravascular and intraparenchymatous hepatic segmentary sclerosis

Abstract

Purpose: To evaluate the morphological effects of injected sclerosing agents into the liver. Methods: This study was performed on twenty dogs, distributed into five groups: Group 1 (n = 5)-control, Group 2 (n = 5)-injection of 50% glucose solution inside hepatic parenchyma and animals followed during seven days, Group 3 (n = 10)-injection of ethanol inside hepatic parenchyma and animals distribution into two subgroups Subgroup 3A (n = 5)-followed during 24 hours and subgroup 3B (n = 5)-followed during seven days (group 3B), Group 4 (n = 5)-ethanol injection inside left portal vein branch and followed during 24 hours. Livers were macroscopically evaluated, submitted to hepatic arteriography and portography, then histology. Results: All animals in Group 4 died within 23 hours due to diffuse hepatic necrosis. The animals of groups 2 and 3 had a satisfactory evolution. Fibrosis formed in the segment reached by the sclerosant solution and interruption of the contrast flow injected into the portal system. Conclusion: Intrahepatic parenchymal ethanol injection is well tolerated and causes sclerosis restricted to a specific segment; however, intraportal ethanol injection causes massive hepatic necrosis and can lead to death.

Hepatic artery disorders associated with alcoholism

“…The indications for liver transplantation in the present study do not differ from those described in the literature. 28 – 31 , 37 …”

“…44 Total sclerosing cholangitis prevents biliary drainage, and the resulting intrahepatic cholestasis damages hepatocytes. 37 In contrast, most patients with alcoholism do not have a previous history of liver disease, and it takes a long time for their hepatocyte reserve to be substantially depleted by heavy alcohol consumption. [28][29][30][31] All the hepatic arteries collected by the Pathology Service that were in good enough Data are numbers (percentages).…”

“…Furthermore, alcoholism is associated with atherosclerosis and thromboembolism. [13][14][15][16][17][18]34,35,37,38 Previous studies have shown that alcohol consumption tends to increase the stability of atheromatous plaques in large arteries, such as the aorta and the common iliac and femoral arteries, but this benefit has not been demonstrated in small and medium-sized arteries, including the coronary and hepatic arteries. [39][40][41][42] In the present study, the arterial wall defects of two groups of patients who underwent liver transplantation because of severe cirrhosis, the first because of alcoholism and the second because of other causes, were compared.…”

“…The indications for liver transplantation in the present study do not differ from those described in the literature. [28][29][30][31]37 The participants in the Non-alcoholism group 2 rarely consumed alcohol, and most did not drink alcoholic beverages at all, mainly to prevent aggravation of their liver disease. Liver transplantation was typically recommended to individuals in this group at a younger age than for those in the Alcoholism group.…”