The role of vitamin C in the gene expression of oxidative stress markers in fibroblasts from burn patients

Bonucci, Jéssica; Gragnani, Alfredo; Trincado, Marcelo Moraes; Vincentin, Victor; Correa, Silvana Aparecida Alves; Ferreira, Lydia Masako

doi:10.1590/s0102-865020180080000006

Cited by 12 publications

(6 citation statements)

References 25 publications

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“…Very interesting observations concern skin fibroblasts obtained from patients with burns. Cells were used to study the effect of AA (250 µM) on 84 genes associated with oxidative stress [101]. Among 10 significantly upregulated genes Ring Finger Protein 7 (RNF7) was identified (3.38-fold increase in expression).…”

Section: Vitamin C and Oxidative Dna Damagementioning

confidence: 99%

Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent

et al. 2020

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Vitamin C has been known for decades. It is common in everyday use as an element of the diet, supplementation, and a preservative. For years, research has been conducted to precisely determine the mechanism of action of ascorbate in the cell. Available results indicate its multi-directional cellular effects. Vitamin C, which belongs to antioxidants scavenging free radicals, also has a ‘second face’—as a pro-oxidative factor. However, whether is the latter nature a defect harmful to the cell, or whether a virtue that is a source of benefit? In this review, we discuss the effects of vitamin C treatment in cancer prevention and the role of ascorbate in maintaining redox balance in the central nervous system (CNS). Finally, we discuss the effect of vitamin C supplementation on biomarkers of oxidative DNA damage and review the evidence that vitamin C has radioprotective properties.

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Section: Vitamin C and Oxidative Dna Damagementioning

confidence: 99%

Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent

et al. 2020

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“…One of the important pathophysiological elements of burns is the development of oxidative stress. Perfusion of ischemic tissues after a thermal trauma results in an imbalance between reactive oxygen species (RTF), and the antioxidant defense system due to the excessive production of free radicals [64]. Therefore, oxidative stress is a state of imbalance between the action of RTF and the biological ability to quickly detoxify reactive intermediates and repair the damage that has occurred.…”

Section: Oxidative Stress In Burned Patientsmentioning

confidence: 99%

Burn Wound Healing: Clinical Complications, Medical Care, Treatment, and Dressing Types: The Current State of Knowledge for Clinical Practice

Markiewicz-Gospodarek

Kozioł

Tobiasz³

et al. 2022

IJERPH

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According to the World Health Organization (WHO), it is estimated that each year approximately 11 million people suffer from burn wounds, 180,000 of whom die because of such injuries. Regardless of the factors causing burns, these are complicated wounds that are difficult to heal and are associated with high mortality rates. Medical care of a burn patient requires a lot of commitment, experience, and multidirectional management, including surgical activities and widely understood pharmacological approaches. This paper aims to comprehensively review the current literature concerning burn wounds, including classification of burns, complications, medical care, and pharmacological treatment. We also overviewed the dressings (with an emphasis on the newest innovations in this field) that are currently used in medical practice to heal wounds.

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“…Esos efectos son el resultado de la acción sobre la microcirculación de mediadores químicos inflamatorios y de la excesiva producción de especies reactivas de oxígeno y nitrógeno que, unidas a la disminución de la capacidad antioxidante, alteran el balance fisiológico de óxido-reducción, dando paso a uno de los mecanismos que pueden agravar la filtración capilar y el shock: el estado de estrés oxidativo. (1)(2)(3) La terapia más importante para mantener la estabilidad hemodinámica es la administración temprana de líquidos por vía parenteral, pero cuando el organismo no logra controlar por mecanismos endógenos los múltiples factores que provocan la disfunción vascular y la inflamación, el riesgo de complicaciones por edema en la etapa posterior a la reanimación hídrica puede ser el resultado final. (4,5) Con independencia de la fórmula de hidratación que se decida emplear, el objetivo del tratamiento en la etapa aguda de la evolución del paciente quemado es perfundir adecuadamente los tejidos pero con el menor aporte posible de fluidos; (5) para lograrlo, se han propuesto varias intervenciones como coadyuvantes al tratamiento de reanimación.…”

Section: Introductionunclassified