2018
DOI: 10.1590/s0102-865020180050000005
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Abstract: 1 5-Experimental SurgeryActa Cir Bras. 2018;33(5):431-438 Abstract Purpose: To evaluate the effects of this thymol-rich oil in the proliferation of human adipose tissue-derived stem cells. Methods: Stem cells were isolated from human adipose tissue by liposuction . After the first passage, cells were cultivated in triplicate for three days in control medium and medium supplemented with three oil samples (1.0 μg/mL, 5.0 μg/mL, and 25.0 μg/mL). Cells were analyzed by the MTT assay at passage 1 (P1), and cell pro… Show more

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Cited by 4 publications
(3 citation statements)
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“…Therefore, increased survival of MSCs by these compounds may be associated with improving therapeutic efficacy. In agreement with our results, supplementing culture medium of adipose tissue-derived stem cells with Thymol-rich essential oil of Lippia origanoides increased the viability and cell proliferation (Brito et al, 2018). In line, Thymol/Carvacrol and the essential oil have been shown to improve wound healing by stimulating tissue development as well as promoting survival and growth of fibroblasts and keratinocytes (Costa et al, 2019).…”
Section: Resultssupporting
confidence: 90%
“…Therefore, increased survival of MSCs by these compounds may be associated with improving therapeutic efficacy. In agreement with our results, supplementing culture medium of adipose tissue-derived stem cells with Thymol-rich essential oil of Lippia origanoides increased the viability and cell proliferation (Brito et al, 2018). In line, Thymol/Carvacrol and the essential oil have been shown to improve wound healing by stimulating tissue development as well as promoting survival and growth of fibroblasts and keratinocytes (Costa et al, 2019).…”
Section: Resultssupporting
confidence: 90%
“…Multiple BMPs, including BMP2, BMP6, BMP7 and BMP9, promote osteoblastic differentiation of MSCs both in vitro and in vivo [40]. Supplementing the culture medium of human adipose tissue-derived MSCs with oil rich in thymol of Lippia origanoides increased cell proliferation, especially at later passages [41]. This essential oil has the potential to become a cheap and efficient means for optimally expanding adult stem cells in vitro for cell therapy.…”
Section: Resultsmentioning
confidence: 99%
“…p-cymene and myrcene, and the sesquiterpene caryophyllene 135 . The supplementation of the essential oil from L. origanoides (1 g/mL) in the culture medium of stem cells isolated from human adipose tissue induced a strong increase of cell proliferation especially at passage 3 136 . The Authors suggested that this effect could be attributed to thymol, the principal constituent of the oil of L. origanoides used in the study (88.2%).…”
Section: Rejuvenation Researchmentioning
confidence: 99%