Effect of melatonin on antioxidant capacity, ınflammation and apoptotic cell death in lung tissue of diabetic rats

Önk, Didem; Onk, Oruç Alper; Erol, Hüseyin Serkan; Özkaraca, Mustafa; Çomaklı, Selim; Ayazoğlu, Tülin Akarsu; Kuyrukluyıldız, Ufuk; Ünver, Süheyla

doi:10.1590/s0102-865020180040000009

Cited by 28 publications

(12 citation statements)

References 26 publications

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“…On the model of bacterial pneumonia, LPS-induced ALI mouse model, it was shown that melatonin successfully inhibits pneumonia through interfering with NLRP3 inflammasome, protecting macrophages from pyroptosis [40]. Other publications also demonstrate that melatonin may be an effective inhibitor of pyroptosis and pathologies associated with it [41][42][43][44][45][46].…”

Section: Coronavirus Activates Inflammasome and Causes Inflammation mentioning

confidence: 99%

Can melatonin reduce the severity of COVID-19 pandemic?

Shneider

Kudriavtsev

Vakhrusheva

2020

International Reviews of Immunology

141

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The current COVID-19 pandemic is one of the most devastating events in recent history. The virus causes relatively minor damage to young, healthy populations, imposing life-threatening danger to the elderly and people with diseases of chronic inflammation. Therefore, if we could reduce the risk for vulnerable populations, it would make the COVID-19 pandemic more similar to other typical outbreaks. Children don't suffer from COVID-19 as much as their grandparents and have a much higher melatonin level. Bats are nocturnal animals possessing high levels of melatonin, which may contribute to their high anti-viral resistance. Viruses induce an explosion of inflammatory cytokines and reactive oxygen species, and melatonin is the best natural antioxidant that is lost with age. The programmed cell death coronaviruses cause, which can result in significant lung damage, is also inhibited by melatonin. Coronavirus causes inflammation in the lungs which requires inflammasome activity. Melatonin blocks these inflammasomes. General immunity is impaired by anxiety and sleep deprivation. Melatonin improves sleep habits, reduces anxiety and stimulates immunity. Fibrosis may be the most dangerous complication after COVID-19. Melatonin is known to prevent fibrosis. Mechanical ventilation may be necessary but yet imposes risks due to oxidative stress, which can be reduced by melatonin. Thus, by using the safe over-the-counter drug melatonin, we may be immediately able to prevent the development of severe disease symptoms in coronavirus patients, reduce the severity of their symptoms, and/or reduce the immuno-pathology of coronavirus infection on patients' health after the active phase of the infection is over. ARTICLE HISTORY

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Section: Coronavirus Activates Inflammasome and Causes Inflammation mentioning

confidence: 99%

Can melatonin reduce the severity of COVID-19 pandemic?

Shneider

Kudriavtsev

Vakhrusheva

2020

International Reviews of Immunology

141

View full text Add to dashboard Cite

show abstract

“…On the model of bacterial pneumonia, LPS-induced ALI mouse model, it was shown that melatonin successfully inhibits pneumonia through interfering with NLRP3 inflammasome, protecting macrophages from pyroptosis [41]. Other publications also demonstrate that melatonin may be an effective inhibitor of pyroptosis and pathologies associated with it [42,43,44,45,46,47].…”

Section: Coronavirus Activates Inflammasome and Causes Inflammation mentioning

confidence: 99%

Can Melatonin Reduce the Severity of COVID-19 Pandemic?

Shneider

Kudriavtsev

Vakhrusheva

2020

Preprint

View full text Add to dashboard Cite

The current COVID-19 pandemic is one of the most devastating events in recent history. The virus causes relatively minor damage to young, healthy populations, imposing life-threatening danger to the elderly and people with diseases of chronic inflammation. Therefore, if we could reduce the risk for vulnerable populations, it would make the COVID-19 pandemic more similar to other typical outbreaks. Children don’t suffer from COVID-19 as much as their grandparents and have a much higher melatonin level. Bats are nocturnal animals possessing high levels of melatonin, which may contribute to their high anti-viral resistance. Viruses induce an explosion of inflammatory cytokines and reactive oxygen species, and melatonin is the best natural antioxidant that is lost with age. The programmed cell death coronaviruses cause, which can result in significant lung damage, is also inhibited by melatonin. Coronavirus causes inflammation in the lungs which requires inflammasome activity. Melatonin blocks these inflammasomes. General immunity is impaired by anxiety and sleep deprivation. Melatonin improves sleep habits, reduces anxiety and stimulates immunity. Fibrosis may be the most dangerous complication after COVID-19. Melatonin is known to prevent fibrosis. Mechanical ventilation may be necessary but yet imposes risks due to oxidative stress, which can be reduced by melatonin. Thus, by using the safe over-the-counter drug melatonin, we may be immediately able to prevent the development of severe disease symptoms in coronavirus patients, reduce the severity of their symptoms, and/or reduce the immuno-pathology of coronavirus infection on patients’ health after the active phase of the infection is over.

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“…The third group rats were administered STZ at 50 mg/kg/i.p. (dissolved in 0.1 mmol/l citrate buffer, pH 4.5) after 12 h fasting at the beginning of the experiment [18].…”

Section: Experimental Designmentioning

confidence: 99%

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B₁

Aleissa

Alkahtani

Eldaim

et al. 2020

Oxidative Medicine and Cellular Longevity

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The current study was carried out to evaluate the ameliorative effect of fucoidan against aflatoxicosis-induced hepatorenal toxicity in streptozotocin-induced diabetic rats. Sixty-four Wister albino male rats were randomly assigned into eight groups (8 rats each) that received normal saline, fucoidan (FUC) at 100 mg/kg/day orally for 4 weeks, streptozotocin (STZ) at 50 mg/kg/i.p. single dose, STZ plus FUC, aflatoxin B 1 (AFB 1 ) at 50 μg/kg/i.p. after one month of the beginning of the experiment for 2 weeks, AFB 1 plus FUC, STZ plus AFB 1 , or STZ plus AFB 1 and FUC. Injection of rats with STZ induced hyperglycemia. Rats with STZ-induced diabetes, with or without AFB 1 intoxication, had significantly elevated activities of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, and levels of serum urea, creatinine, cholesterol, 8-oxo-2′-deoxyguanosine, interleukin-1β, interleukin-6, and tumor necrosis factor-α. In addition, these rats exhibited increased lipid peroxidation and reduced glutathione concentration and activities of superoxide dismutase, catalase, and glutathione peroxidase enzymes in the hepatic and renal tissues. In contrast, administration of FUC to diabetic rats, with or without AFB 1 intoxication, ameliorated the altered serum parameters, reduced oxidative stress, DNA damage, and inflammatory biomarkers, and enhanced the antioxidant defense system in the hepatic and renal tissues. These results indicated that FUC ameliorated diabetes and AFB 1 -induced hepatorenal injuries through alleviating oxidative stress, DNA damage, and inflammation.

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Effect of melatonin on antioxidant capacity, ınflammation and apoptotic cell death in lung tissue of diabetic rats

Abstract: The melatonin caused an increase in antioxidant capacity and decreased the expression of cleaved-caspase 3.

Cited by 28 publications

References 26 publications

Can melatonin reduce the severity of COVID-19 pandemic?

Can melatonin reduce the severity of COVID-19 pandemic?

Can Melatonin Reduce the Severity of COVID-19 Pandemic?

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B₁

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Effect of melatonin on antioxidant capacity, ınflammation and apoptotic cell death in lung tissue of diabetic rats

Abstract: The melatonin caused an increase in antioxidant capacity and decreased the expression of cleaved-caspase 3.

Cited by 28 publications

References 26 publications

Can melatonin reduce the severity of COVID-19 pandemic?

Can melatonin reduce the severity of COVID-19 pandemic?

Can Melatonin Reduce the Severity of COVID-19 Pandemic?

Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B1

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Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B₁