2018
DOI: 10.1590/s0102-865020180040000008
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Abstract: Purpose: To investigate the prophylactic and therapeutical effects of sildenafil in a model of acute radiation proctitis (ARP). Methods: All experimental procedures of this study was examined by histopathological, immunohistochemical and transmission electron microscopic analysis. Results: Our histopathological evaluations indicated significant increases in lesion severity, cryptic apsis, cryptitis, cryptic distortion, reactive atypia and infiltration depth of the control (proctitis) group. While the prophylax… Show more

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Cited by 5 publications
(2 citation statements)
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“…There are various treatments for radiation proctitis and these include medical therapies, hyperbaric oxygen and endoscopic therapies 20 . Many medical therapies have been proposed and developed, including anti-inflammatory agents (sulphasalazine, balsalazide and mesalazine), antioxidants (vitamin A, E and C) 21 , 22 , mucosal protectants (formalin, sildenafil and mesenchymal stem cell) 23 , 24 and so on. Apart from medical therapies, hyperbaric Oxygen appears to be an effective therapy for radiation proctitis according to some clinical trials 25 .…”
Section: Discussionmentioning
confidence: 99%
“…There are various treatments for radiation proctitis and these include medical therapies, hyperbaric oxygen and endoscopic therapies 20 . Many medical therapies have been proposed and developed, including anti-inflammatory agents (sulphasalazine, balsalazide and mesalazine), antioxidants (vitamin A, E and C) 21 , 22 , mucosal protectants (formalin, sildenafil and mesenchymal stem cell) 23 , 24 and so on. Apart from medical therapies, hyperbaric Oxygen appears to be an effective therapy for radiation proctitis according to some clinical trials 25 .…”
Section: Discussionmentioning
confidence: 99%
“…Sildenafil not only modulated skin injury and promoted its reconstruction, but also shortened the repairing time [171]. Prophylaxis and treatment with sildenafil modified radiation‐induced proctitis in the rats, lowered the histopathological score, and reduced the production of inflammatory cytokines [172].…”
Section: Sildenafil and Cancermentioning
confidence: 99%