Investigation of the effect of gestational diabetes on fetal cardiac tissue in streptozotocin ınduced in rats

Turhan, Uğur; Yılmaz, Ercan; Gül, Mehmet; Melekoğlu, Rauf; Türköz, Yusuf; Özyalın, Fatma; Parlakpınar, Hakan; Şimşek, Yavuz

doi:10.1590/s0102-865020180040000002

Cited by 8 publications

(4 citation statements)

References 15 publications

(15 reference statements)

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“…However, the majority of women with GDM are not obese (Coustan et al 2010, Lapolla et al 2011, and the commonly used dosages of STZ cause dramatic loss of beta-cells and consequently hyperglycemia, similar to type 1 diabetes prior to pregnancy. Furthermore, STZ given during gestation to limit the hyperglycemia to late pregnancy has been reported to have harmful effects on fetal development (Giavini et al 1986, Kalter 1996, Turhan et al 2018. To circumvent these pitfalls, we decided to develop a combined treatment protocol that includes a short HFD feeding, which would not induce drastic body weight gain (Fig.…”

Section: Journal Of Endocrinologymentioning

confidence: 99%

A mouse model of gestation-specific transient hyperglycemia for translational studies

Liu

Harvey

et al. 2020

Journal of Endocrinology

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The prevalence of gestational diabetes mellitus (GDM) is estimated at 14% globally, and in some countries, such as Singapore, exceeds 20%. Both women and children exposed to GDM have an increased risk of later metabolic diseases, cardiovascular disease and other health issues. Beyond lifestyle changes and pharmaceutical intervention using existing type 2 diabetes medications for expecting women, there are limited treatment options for women with GDM; targeting better outcomes of potentially affected infants is unexplored. Numerous animal models have been generated for understanding of pathological processes of GDM development and for development of treatment strategies. These models, however, suffer from limited windows of opportunity to examine risk factors and potential intervention options. By combining short-term high-fat diet (HFD) feeding and low-dose streptozotocin (STZ) treatments before pregnancy, we have established a mouse model with marked transient gestation-specific hyperglycemia, which allows testing of nutritional and pharmacological interventions before, during and beyond pregnancy.

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Section: Journal Of Endocrinologymentioning

confidence: 99%

A mouse model of gestation-specific transient hyperglycemia for translational studies

Liu

Harvey

et al. 2020

Journal of Endocrinology

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“…A subsequent study conducted on a rat model of streptozotocin-induced GDM revealed that elevated levels of free oxygen radicals, attributed to hyperglycemia, have the potential to disrupt cell homeostasis and negatively impact mitosis. This disruption during the organogenesis period may lead to the development of congenital cardiac anomalies [49]. Additionally, a recent study utilizing the same model demonstrated that GDM can also induce hypertrophic cardiomyopathy through alterations in the expression of microRNA 21 and 23b [50].…”

Section: Discussionmentioning

confidence: 99%

Maternal Gestational Diabetes Mellitus and Congenital Heart Disease in Offspring: A Meta-Analysis

Liu,

Yue,

Chang

2024

Horm Metab Res

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Maternal diabetes has been related to an increased risk of congenital heart disease (CHD) in offspring. However, inconsistent results were retrieved for studies evaluating the association between gestational diabetes mellitus (GDM) and CHD in offspring. We therefore performed a systematic review and meta-analysis for comprehensive investigation. Observational studies were identified by searching PubMed, Embase, and Web of Science according to the aim of the meta-analysis. A randomized-effects model was used to pool the data by incorporating the influence of potential heterogeneity. Twenty-three observational studies, involving 46953078 mother-child pairs, were available for the meta-analysis. Among them, 2131800 mothers were diagnosed as GDM and 214379 newborns had CHD. Overall, maternal GDM was associated with a higher incidence of CHD in offspring [odds ratio (OR): 1.32, 95% confidence interval (CI): 1.21 to 1.45, p<0.001; I2=62%]. Sensitivity analysis limited to studies with adjustment of maternal age and other potential confounding factors showed similar results (OR: 1.40, 95% CI: 1.30 to 1.51, p<0.001; I2=47%). Subgroup analysis suggested that the association between maternal GDM and CHD in offspring was not significantly affected by methods for diagnosis of GDM, methods for confirmation of CHD, or study quality scores (p for subgroup difference all>0.05). Subsequent analysis according to types of CHD showed that maternal GDM was associated with higher risks of atrial septal defect, ventricular septal defect, and Tetralogy of Fallot. Maternal GDM may be associated with a higher risk of CHD in offspring.

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“…2018;33(6):499-507 whereas high ROS activity negatively affects intracellular homeostasis by causing cell cycle arrest, cell dysfunction and consequent DNA damage 12 . This is especially shown as the cause of chemotherapy-induced cytotoxicity.…”

Section: ■ Discussionmentioning

confidence: 99%

The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats

et al. 2018

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Purpose: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects. Methods: A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (100mg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group. Results: Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin. Conclusion: Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin.

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Investigation of the effect of gestational diabetes on fetal cardiac tissue in streptozotocin ınduced in rats

Abstract: Increased levels of free oxygen radicals considered to be due to hyperglycemia may cause congenital anomalies, especially during organogenesis period, by disrupting cell homeostasis and adversely affecting mitosis.

Cited by 8 publications

References 15 publications

A mouse model of gestation-specific transient hyperglycemia for translational studies

A mouse model of gestation-specific transient hyperglycemia for translational studies

Maternal Gestational Diabetes Mellitus and Congenital Heart Disease in Offspring: A Meta-Analysis

The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats

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