2018
DOI: 10.1590/s0102-865020180040000001
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Abstract: Postoperative enteral administration of cilostazol increased blood flow and decreased the total area of necrosis of avulsed cutaneous flaps of rat limbs.

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(4 citation statements)
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“…6 No signs of flap ischemia or necrosis were also observed using cilostazol 30 mg/kg twice a day, starting immediately after surgery and continuing for 7 days, without using it in the preoperative period. 13 When the same dose is not given for 7 days in the preoperative period, this demonstrates that it will result in higher rates of flap necrosis compared with the groups in which it was presented during the operative period for 14 days, not only in the preoperative period. 4 Although most studies demonstrate a beneficial effect of these medications on the circulation of flaps, there was no consensus regarding the dose and time of use in the pre-or postoperative period, with use ranging from 1 week preoperatively, 12 to 1 week postoperative.…”
Section: Discussionmentioning
confidence: 97%
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“…6 No signs of flap ischemia or necrosis were also observed using cilostazol 30 mg/kg twice a day, starting immediately after surgery and continuing for 7 days, without using it in the preoperative period. 13 When the same dose is not given for 7 days in the preoperative period, this demonstrates that it will result in higher rates of flap necrosis compared with the groups in which it was presented during the operative period for 14 days, not only in the preoperative period. 4 Although most studies demonstrate a beneficial effect of these medications on the circulation of flaps, there was no consensus regarding the dose and time of use in the pre-or postoperative period, with use ranging from 1 week preoperatively, 12 to 1 week postoperative.…”
Section: Discussionmentioning
confidence: 97%
“…6 No signs of flap ischemia or necrosis were also observed using cilostazol 30 mg/kg twice a day, starting immediately after surgery and continuing for 7 days, without using it in the preoperative period. 13 When the same dose is not given for 7 days in the preoperative period, this demonstrates that it will result in higher rates of flap necrosis compared with the groups in which it was presented during the operative period for 14 days, not only in the preoperative period. 4…”
Section: Discussionmentioning
confidence: 97%
See 2 more Smart Citations