2018
DOI: 10.1590/s0102-865020180030000007
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Abstract: Propofol significantly increases the expression of HO-1 in the lung tissueand prevents changes in lung morphology due to ALI in rats.

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Cited by 4 publications
(5 citation statements)
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“…In present study, we established the modified rat CPB model. Consistent with other observations (7,11), our results demonstrated HO-1 was strongly expressed after CPB in the lung tissue in the CPB-induced LI model. Increased expression of HO-1 in rat lung tissue after CPB showed that CPB brought about reperfusion injury and also activated the high expression of HO-1 as a protective mechanism at the same time.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…In present study, we established the modified rat CPB model. Consistent with other observations (7,11), our results demonstrated HO-1 was strongly expressed after CPB in the lung tissue in the CPB-induced LI model. Increased expression of HO-1 in rat lung tissue after CPB showed that CPB brought about reperfusion injury and also activated the high expression of HO-1 as a protective mechanism at the same time.…”
Section: Discussionsupporting
confidence: 93%
“…HO-1 provides an inducible defense mechanism that can be activated ubiquitously in cells and tissues in response to noxious stimuli, conferring cellular protection against injury inflicted by such stimuli (11). In present study, in the context of CPB-induced LI, we still confirmed this inducible defense mechanism.…”
Section: Discussionsupporting
confidence: 75%
“…Propofol is frequently used as an anesthetic; however, it possesses a variety of activities, including anti-inflammatory activity (15)(16)(17)(18)(19)(20). Although previous studies observed the protective effects of propofol in ALI (21)(22)(23), its mechanism of action requires further investigation, and the role of propofol in neonatal ALI has not been previously examined, to the best of the authors' knowledge. The present study aimed to investigate the effects of propofol on neonatal ALI and to investigate its mechanism of action.…”
Section: Discussionmentioning
confidence: 90%
“…Liu et al (22) suggested that propofol increased the effect of sevoflurane in relieving LPS-induced ALI in mice. A recent study demonstrated that treatment with propofol significantly increased the expression levels of heme oxygenase 1 in lung tissues and inhibited the lung morphological alterations caused by ALI in rats (23). Additionally, the p38 mitogen-activated protein kinase (MAPK)/nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) signaling pathway and the NLR family pyrin domain containing 3 (NLRP3) inflammasome, which serve roles in the regulation of inflammation, were identified to be regulated by propofol (20,24).…”
Section: Introductionmentioning
confidence: 99%
“…A previous study stated that I/R injury could increase W/D ratio while decreasing PaO 2 level (Zou and Sun 2020). PaO 2 can be significantly improved by the pretreatment of Propofol along with reduced lung W/D weight ratio in lung tissues of rats with oleic acid-induced acute lung injury (Tan et al 2018). Therefore, it was reasonable to conclude that Propofol alleviated I/R in vivo.…”
Section: Discussionmentioning
confidence: 99%