Effect of a new cross-linked hyaluronan gel on the staple line after sleeve gastrectomy in a rat model

Bülbüller, Nurullah; Karakaş, Barış Rafet; Yıldırım, Hülya Tosun; Yaprak, Muhittin; Vural, Veli; Akbas, S. Halide; Karaveli, Arzu; Sezer, Cem

doi:10.1590/s0102-865020180020000008

Cited by 1 publication

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“…Many techniques, methods, and materials such as amnion matrix patch, omental graft, fibrin glue, etc. were used to prevent these complications 9 - 10 . Unfortunately, despite of all attempts, these complications remain a common problem after obesity surgery 2 - 6 .…”

Section: Discussionmentioning

confidence: 99%

“…Cut surface leakage after SG is the most feared complication with incidence of 0-7% [3][4][5][6][7][8] . Some different tools and techniques have been used to strengthen the cutting surface, such as glycolide-trimethylene carbonate copolymer, bovine pericardial strips, fibrin glue, amniotic membrane, proteinrich plasma, and various hemostatic agents [9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

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Effects of glycerol and sodium pentaborate containing new formulation on sleeve gastrectomy model in rats

et al. 2021

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Purpose:The development of cutting surface leakage and postoperative peritoneal adhesions (PPA) after sleeve gastrectomy (SG) are the most serious operative complications. We investigated the effectiveness of the newly developed glycerol and sodium pentaborate containing formulation on the prevention of these complications. Methods: Sixteen Sprague Dawley rats (mean weight 310 ± 50 g, mean age 3 months old) were divided into two groups, consisting of eight rats in each. SG and a double-layer suture technique were performed for each group. In study group, there was the mixture of 2 mL 3% glycerol plus 3% sodium pentaborate formulation, and in the control group 2 mL 0.9% NaCl was injected into the peritoneal cavity. Rats were sacrificed after 30 days, then macroscopic adhesion grade scoring and histopathological evaluations were assessed. Results: Macroscopic PPA scores in the control and study groups were 2.75 ± 0.16 and 1.50 ± 0.327, respectively (p = 0.004). Histopatologic fibrosis scores in the control and study groups were 0.87 ± 0.125 and 2.00 ± 0.26, respectively (p = 0.002). Conclusions: In SG operation model, glycerol plus sodium pentaborate compound decreased PPA formation and also increased stomach cut surface line fibrosis. This new formulation is hopeful for more safe SG operations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of glycerol and sodium pentaborate containing new formulation on sleeve gastrectomy model in rats

et al. 2021

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Effect of a new cross-linked hyaluronan gel on the staple line after sleeve gastrectomy in a rat model

Abstract: New cross-linked hyaluronan gel could be an effective approach to improve staple line wound healing and prevent potential leakage after sleeve gastrectomy. Moreover, NCHA gel helps to prevent adhesion formation without compromising healing of the staple line.

Cited by 1 publication

References 26 publications

Effects of glycerol and sodium pentaborate containing new formulation on sleeve gastrectomy model in rats

Effects of glycerol and sodium pentaborate containing new formulation on sleeve gastrectomy model in rats

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