Protective effect of dexmedetomidine against myocardial ischemia-reperfusion injury in rabbits

Ren, Jianjun; Li, Changfa; Liu, Yan; Dong, Zhao

doi:10.1590/s0102-865020180010000003

Cited by 10 publications

(7 citation statements)

References 29 publications

(28 reference statements)

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“…TNF-α and IL-1β are responsible for the stimulation of chemokines and the secretion of adhesion molecules in ischemic tissues, and IL-6 is responsible for the regulation of inflammation ( 37 , 38 ). Previous studies have reported that Dex induces multiple protective effects on MIRI ( 39 ), and such findings were further supported by the present study. Yu et al ( 40 ) have reported that microRNA-665 and Dex protect cardiomyocytes against I/R injury caused by oxide stress and suppress apoptosis.…”

Section: Discussionsupporting

confidence: 91%

Protective effects of dexmedetomidine on hypoxia/reoxygenation injury in cardiomyocytes by regulating the CHOP signaling pathway

Shi

Liu

2020

Mol Med Rep

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Hypoxia/reoxygenation (H/r) injury in myocardial cells occurs frequently during cardiac surgery and affects the prognosis of patients. The present study aimed to investigate the protective effects of dexmedetomidine (dex) on H/r injury and its association with the c/eBP-homologous protein (cHoP) signaling pathway. an H/r model was constructed in H9c2 cells to investigate the effects of dex on H/r injury. cell viability, apoptosis and lactate dehydrogenase (LDH) levels were determined by MTT, flow cytometry and 2,4-dinitrophenylhydrazine colorimetric assays, respectively. The expression levels of inflammatory factors were measured by reverse transcription-quantitative Pcr (rT-qPcr), and cHoP and glucose-regulated protein-78 (Grp78) expression levels were detected by rT-qPcr and western blotting. cHoP was overexpressed or knocked down to detect the cell viability, apoptosis, LDH level and the expression levels of inflammatory factors and Grp78. The results demonstrated that in the H/r group, cell viability was lower and apoptosis was higher, and that higher levels of LDH and inflammatory factors were present compared with those in the dex+H/r group. Silencing of CHOP significantly reversed the H/R-reduced cell viability, high apoptotic rate and ldH levels, as well as the elevated expression levels of inflammatory factors and Grp78 caused by H/r injury, whereas the overexpression of cHoP inhibited cell viability and promoted apoptosis, elevated ldH level and expression of inflammatory factors and Grp78 compared with the negative control. additionally, pretreatment with Dex significantly alleviated the H/R injury; thus, Dex may protect H9c2 cells against H/r induced cell injury, possibly by suppressing the cHoP signaling pathway.

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Section: Discussionsupporting

confidence: 91%

Protective effects of dexmedetomidine on hypoxia/reoxygenation injury in cardiomyocytes by regulating the CHOP signaling pathway

Shi

Liu

2020

Mol Med Rep

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“…Dexmedetomidine is an alpha-adrenergic receptor agonist drug and extensively used as a sedative. Dexmedetomidine protects against myocardial infarction [125], ischemic brain [126] and kidney injury [127]. Previous studies have shown that preconditioning with Dex in rats has a protective effect on the renal function after I-R through the inhibition of the Janus kinase/signal transducers and activators of the transcription (JAK/STAT) signaling pathway [128].…”

Section: Other Anesthetics In Irimentioning

confidence: 99%

Opioids Preconditioning Upon Renal Function and Ischemia-Reperfusion Injury: A Narrative Review

et al. 2019

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Kidneys have an important role in regulating water volume, blood pressure, secretion of hormones and acid-base and electrolyte balance. Kidney dysfunction derived from acute injury can, under certain conditions, progress to chronic kidney disease. In the late stages of kidney disease, treatment is limited to replacement therapy: Dialysis and transplantation. After renal transplant, grafts suffer from activation of immune cells and generation of oxidant molecules. Anesthetic preconditioning has emerged as a promising strategy to ameliorate ischemia reperfusion injury. This review compiles some significant aspects of renal physiology and discusses current understanding of the effects of anesthetic preconditioning upon renal function and ischemia reperfusion injury, focusing on opioids and its properties ameliorating renal injury. According to the available evidence, opioid preconditioning appears to reduce inflammation and reactive oxygen species generation after ischemia reperfusion. Therefore, opioid preconditioning represents a promising strategy to reduce renal ischemia reperfusion injury and, its application on current clinical practice could be beneficial in events such as acute renal injury and kidney transplantation.

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“…Dex is widely used in clinical scenarios and recent studies have indicated that the use of Dex is advantageous in reducing anesthetic requirements and enhancing hemodynamic stability following cardiac surgery (6). Dex pre-conditioning and Dex perfusion during the whole surgery have been examined in a variety of animal models of ischemia-reperfusion and have been demonstrated to protect multiple organs and provide a protective effect against MIRI (7)(8)(9). Furthermore, clinical study have suggested that Dex perfusion during the whole cardiac surgery under CPB reduces the risk of postoperative MIRI (10).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of dexmedetomidine on the ischemic myocardium in patients undergoing rheumatic heart valve replacement surgery

et al. 2021

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The aim of the present study was to compare the effects of two methods of dexmedetomidine (Dex) administration on myocardial injury, inflammation and stress in ischemic myocardium during rheumatic heart valve replacement. In total, 90 patients were included in the present study and were divided into the following three groups: i) Dex group (1.0 µg/kg Dex pre-administered 10 min prior to anesthesia, then 0.5 µg/kg/h Dex for maintenance); ii) Dex pre-conditioning group (Pre-Dex; 1.0 µg/kg Dex administered 10 min prior to anesthesia, then saline for maintenance); and iii) control group (saline 10 min prior to anesthesia and saline during maintenance), with 30 patients in each group. Heart rate (HR) and mean artery pressure (MAP) were recorded at eight time-points: i) T1, pre-medication; ii) T2, 10 min post-medication; iii) T3, immediately post-intubation; iv) T4, upon skin incision; v) T5, upon sawing the sternum; vi) T6, immediately post-cardiopulmonary bypass; vii) T7, immediately post-operation; and viii) T8, 24 h post-operation. The serum cardiac troponin I (cTnI), interleukin (IL)-8, IL-10 and malondialdehyde (MDA) levels were also detected at T1, T6, T7 and T8. Blood glucose levels were detected at T1, T5, T6 and T7. In comparison with the control group, patients in the Dex group exhibited a significant increase in cardiac function, as indicated by an increase in HR, MAP and IL-10 levels, and a significant decrease in cTnI, IL-8, MDA and glucose levels. Both Dex perfusion and Dex preconditioning were able to reduce myocardial injury, inflammation, oxidative stress and stress response in rheumatic heart valve replacement surgery. However, Dex perfusion during the whole surgery was more effective than Dex preconditioning treatment. The study was registered with the Chinese Clinical Trial Registry (ChiCTR; no. ChiCTR-INR-17011955).

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Protective effect of dexmedetomidine against myocardial ischemia-reperfusion injury in rabbits

Cited by 10 publications

References 29 publications

Protective effects of dexmedetomidine on hypoxia/reoxygenation injury in cardiomyocytes by regulating the CHOP signaling pathway

Protective effects of dexmedetomidine on hypoxia/reoxygenation injury in cardiomyocytes by regulating the CHOP signaling pathway

Opioids Preconditioning Upon Renal Function and Ischemia-Reperfusion Injury: A Narrative Review

Protective effects of dexmedetomidine on the ischemic myocardium in patients undergoing rheumatic heart valve replacement surgery

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