2017
DOI: 10.1590/s0102-865020170201
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Abstract: 1 1-Experimental SurgeryActa Cir Bras. 2017;32(2):90-97 Abstract Purpose: To evaluate the effect of tadalafil in renal ischemia/reperfusion (I/R) injury in rats. Methods: Group I/R saline rats (n=6) were subjected to 45 minutes of left renal ischemia and treated with saline; the I/R tadalafil rats (n=6) received oral 10mg/kg tadalafil microemulsion one hour before ischemia. In both groups, 8 hours after ischemia, laboratory analysis were performed. Results: Better tissue perfusion was lower in ischemic left/ki… Show more

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Cited by 13 publications
(9 citation statements)
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References 27 publications
(27 reference statements)
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“…5 Renal I/R injury can also induce the acute renal failure, which may lead to some other syndromes, such as acute inflammation and secondary tissue injury. 6 Despite the ongoing research on renal I/R injury, there are still no current effective therapeutic approaches for the treatment of renal I/R injury, which makes the search for new therapeutic tools essential. 7 CD184 or more commonly known as CXCR4 is a chemokine receptor that belongs to the G protein-coupled receptors (GPCR) gene family, and is expressed by cells in the immune and central nervous system.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…5 Renal I/R injury can also induce the acute renal failure, which may lead to some other syndromes, such as acute inflammation and secondary tissue injury. 6 Despite the ongoing research on renal I/R injury, there are still no current effective therapeutic approaches for the treatment of renal I/R injury, which makes the search for new therapeutic tools essential. 7 CD184 or more commonly known as CXCR4 is a chemokine receptor that belongs to the G protein-coupled receptors (GPCR) gene family, and is expressed by cells in the immune and central nervous system.…”
Section: Introductionmentioning
confidence: 99%
“…Patients who survive from acute episodes are still are still not clear of the disease may which may progress to the chronic kidney disease stage that could possibly result in end‐stage renal diseases . Renal I/R injury can also induce the acute renal failure, which may lead to some other syndromes, such as acute inflammation and secondary tissue injury . Despite the ongoing research on renal I/R injury, there are still no current effective therapeutic approaches for the treatment of renal I/R injury, which makes the search for new therapeutic tools essential …”
Section: Introductionmentioning
confidence: 99%
“…The main characteristics and results of the human studies evaluating the potential reno-protective effects of PDE5Is are summarized in Table 1 [17,24,38,39]. The main characteristics and results of the animal studies on currently proposed AKI models evaluating the potential reno-protective effects of sildenafil, tadalafil, icariin, vardenafil, zaprinast-udenafil are summarized in Table 2 [23,30,, Table 3 [29,35,45,49,[62][63][64][65][66][67][68][69][70][71][72][73][74], Table 4 [18,75,76], Table 5 [45,77,78], and Table 6 [21,40,79,80], respectively. The main characteristics and results of the animal studies in the AKI-CKD transition spectrum (focusing on renal function and/or structure alterations for up to three months, not fulfilling the KDIGO definition for CKD [6]) evaluating the potential reno-protective effects of sildenafil, tadalafil, icariin, vardenafil, zaprinast-udenafil are summarized in Table A1 [109,110], respectively (Appendix B).…”
Section: Resultsmentioning
confidence: 99%
“…Tadalafil is a phosphodiesterase-5 (PDE-5) inhibitor that has been reported to exhibit anti-inflammatory activity against different experimental models, including prostate inflammation ( Okamoto et al, 2018 ), liver injury induced by thioacetamide ( Mansour et al, 2018 ), allergic inflammatory airways ( Mokry et al, 2017 ), and renal ischemia/reperfusion ( Medeiros et al, 2017 ). In addition, PDE inhibitors have been documented to be effective in the management of autoimmune diseases, such as RA ( Shenoy and Agarwal, 2010 ).…”
Section: Introductionmentioning
confidence: 99%