Effect of different commercial fat sources on brain, liver and blood lipid profiles of rats in growth phase

Angelis-Pereira, Michel Cardoso de; Barcelos, Maria de Fátima Píccolo; Pereira, Juciane de Abreu Ribeiro; Pereira, Rafaela Corrêa; Souza, Raimundo Vicente de

doi:10.1590/s0102-865020170120000003

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Some studies reported that dietary interventions might change lipid contents in the brain [47,48]. This is consistent with our results since more than half of the brain fatty acid levels were significantly different among groups.…”

Section: Discussionsupporting

confidence: 93%

Non-Alcoholic Fatty Liver Disease, and the Underlying Altered Fatty Acid Metabolism, Reveals Brain Hypoperfusion and Contributes to the Cognitive Decline in APP/PS1 Mice

et al. 2019

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Non-alcoholic fatty liver disease (NAFLD), the leading cause of chronic liver disease, is associated with cognitive decline in middle-aged adults, but the mechanisms underlying this association are not clear. We hypothesized that NAFLD would unveil the appearance of brain hypoperfusion in association with altered plasma and brain lipid metabolism. To test our hypothesis, amyloid precursor protein/presenilin-1 (APP/PS1) transgenic mice were fed a standard diet or a high-fat, cholesterol and cholate diet, inducing NAFLD without obesity and hyperglycemia. The diet-induced NAFLD disturbed monounsaturated and polyunsaturated fatty acid (MUFAs, PUFAs) metabolism in the plasma, liver, and brain, and particularly reduced n-3 PUFAs levels. These alterations in lipid homeostasis were associated in the brain with an increased expression of Tnfα, Cox2, p21, and Nox2, reminiscent of brain inflammation, senescence, and oxidative stress. In addition, compared to wild-type (WT) mice, while brain perfusion was similar in APP/PS1 mice fed with a chow diet, NAFLD in APP/PS1 mice reveals cerebral hypoperfusion and furthered cognitive decline. NAFLD reduced plasma β40- and β42-amyloid levels and altered hepatic but not brain expression of genes involved in β-amyloid peptide production and clearance. Altogether, our results suggest that in a mouse model of Alzheimer disease (AD) diet-induced NAFLD contributes to the development and progression of brain abnormalities through unbalanced brain MUFAs and PUFAs metabolism and cerebral hypoperfusion, irrespective of brain amyloid pathology that may ultimately contribute to the pathogenesis of AD.

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Section: Discussionsupporting

confidence: 93%

Non-Alcoholic Fatty Liver Disease, and the Underlying Altered Fatty Acid Metabolism, Reveals Brain Hypoperfusion and Contributes to the Cognitive Decline in APP/PS1 Mice

et al. 2019

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“…Additionally, there are many reports showing that different classes of fatty acids from diet can produce various hypercholesterolaemia states (de Angelis-Pereira et al. 2017 ). Magri-Tomaz et al.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the toxicology, anti-lipase, and antioxidant effects of Callistemon citrinus in rats fed with a high fat-fructose diet

Ortega-Pérez

Piñón-Simental

Magaña-Rodríguez

et al. 2022

Pharmaceutical Biology

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Context Callistemon citrinus Skeels (Myrtaceae) exhibits many biological activities. Objective This study analyzes for the first time, the toxicity, obesogenic, and antioxidant effects of C. citrinus in rats fed with a high fat-fructose diet (HFFD). Materials and methods Four studies using male Wistar rats were conducted: (a) 7 groups ( n = 3): control (corn oil) and ethanol extract of C. citrinus leaf (single oral dose at 100–4000 mg/kg) for acute toxicity; (b) 2 groups ( n = 8): control (corn oil) and C. citrinus (1000 mg/kg/day) for 28 days for subacute toxicity; (c) 3 groups ( n = 4) with single oral dose of lipid emulsion: control (lipid emulsion), C. citrinus and orlistat (250 and 50 mg/kg, respectively) for lipid absorption; (d) 4 groups ( n = 6): control (normal diet) and 3 groups fed with HFFD: HFFD only, C. citrinus and simvastatin (oral dose 250 and 3 mg/kg, respectively) for 13 weeks. Antioxidant enzymes and biomarkers were evaluated and inhibition of pancreatic lipase was determined in vitro . Results Toxicological studies of C. citrinus showed no differences in biochemical parameters and lethal dose (LD 50 ) was higher than 4000 mg/kg. C. citrinus inhibited pancreatic lipase activity, with IC 50 of 392.00 µg/mL, and decreased lipid absorption by 70%. Additionally, it reduced the body weight 22%, restored the activities of antioxidant enzymes, and reduced the biomarkers of oxidative stress. Conclusions Callistemon citrinus showed an effect against oxidative stress by reducing biomarkers and induced antioxidant system, without toxic effects.

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“…This is similar to the research by Franczyk-Żarów et al and de Angelis-Pereira et al which showed that margarine administration was able to significantly increase TG levels in experimental animals. Meanwhile, liquid butter was able to lower HDL levels better than liquid margarine [15], [16]. Atherogenic index is a potential marker for metabolic-related diseases.…”

Section: Resultsmentioning

confidence: 99%

Long-Term Induction by Duck Egg Yolk Resulting in Increased Total Cholesterol, Low Density Lipoprotein, High Density Lipoprotein and Atherogenic Index in Experimental Animals

Budiyanto¹,

Cholili²,

Adhyaksa³

et al. 2022

Proceedings of the 3rd International Conference on Cardiovascular Diseases (ICCvD 2021)

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Induction by high-fat diet (HFD) is frequently performed for research on hypercholesterolemia in experimental animals. In general, HFD is obtained by combining various components, but only few studies have investigated the potential of each component to induce hypercholesterolemia in experimental animals. This study aimed to identify the potential of a number of HFD components found on a day-to-day basis in society for induction of hypercholesterolemia in animal models. The research involved a posttest only group design conducted on 30 Rattus norvegicus rats for 28 days. In addition to receiving standard ad-libitum feed, the rats were given appropriate treatment according to the group, each at a dose of 1ml/100gBW for P1 = distilled water, P2 = chicken egg yolk, P3 = quail egg yolk, P4 = duck egg yolk, P5 = liquid butter, and P6 = liquid margarine. The lipid profile (total cholesterol, LDL, HDL, triglycerides) was examined at the end of the study. The obtained blood serum was examined using a spectrophotometry to yield the lipid profile data. The atherogenic index (AI) was measured by dividing LDL by HDL. The data were analyzed using a one-way ANOVA. This study showed that induction by duck egg yolk for 28 days resulted in the highest levels of total cholesterol, LDL, HDL, and AI (P4; total cholesterol = 85.00 ± 22.86, LDL = 23.20 ± 9.05, HDL = 37.16 ± 12.21, AI = 0.63 ± 0.12). The induction by liquid margarine was able to result in the highest increase in the triglyceride level compared to the healthy group and other induction of hypercholesterolemia, but there was no difference in the levels of total cholesterol (p = 0.362), LDL (p = 0.112), HDL (p = 0.631), triglycerides (p = 0.427), and AI (0.094). This study shows that duck egg yolk has the potential to be used in induction of hypercholesterolemia in experimental animals..

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Effect of different commercial fat sources on brain, liver and blood lipid profiles of rats in growth phase

Cited by 4 publications

References 24 publications

Non-Alcoholic Fatty Liver Disease, and the Underlying Altered Fatty Acid Metabolism, Reveals Brain Hypoperfusion and Contributes to the Cognitive Decline in APP/PS1 Mice

Non-Alcoholic Fatty Liver Disease, and the Underlying Altered Fatty Acid Metabolism, Reveals Brain Hypoperfusion and Contributes to the Cognitive Decline in APP/PS1 Mice

Evaluation of the toxicology, anti-lipase, and antioxidant effects of Callistemon citrinus in rats fed with a high fat-fructose diet

Long-Term Induction by Duck Egg Yolk Resulting in Increased Total Cholesterol, Low Density Lipoprotein, High Density Lipoprotein and Atherogenic Index in Experimental Animals

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