Tadalafil protector effect during ischemia-reperfusion in rats

Abstract

Tadalafil protector effect during ischemia-reperfusion in rats 1 9-Experimental SurgeryActa Cir Bras. 2017;32(11):973-983 AbstractPurpose: To evaluate histological parameters in rat renal tissue after tadalafil use during hot ischemia for 45 minutes and reperfusion for 24 hours. Methods: Twenty rats were divided into 2 groups. In the experimental group 10 mg/ kg of tadalafil was used per gavage before the procedure. All cases underwent left partial nephrectomy, followed by 45 minutes of warm ischemia. Left nephrectomy of the remaining kidney was performed after 24 hours from the initial procedure. The histological parameters analyzed were: detachment of tubular cells, accumulation of desquamated cells in the proximal tubule, loss of brush border, tubular cylinders, interstitial edema, leukocyte infiltration, capillary congestion, vacuolization, tubular dilatation, necrosis and collapse of the capillary tuft. Results: Two rats from each group died and were excluded from the study. Tadalafil significantly reduced leukocyte infiltration (p = 0.036). The remaining histological parameters did not show statistical difference between the groups. Conclusion: The use of tadalafil during warm ischemia and reperfusion demonstrates statistically significant reduction of leukocyte infiltration in the renal interstitium. 973Tadalafil protector effect during ischemia-reperfusion in rats Wietzikoski EGG et al. Acta Cir Bras. 2017;32(11):973-983 974

Tadalafil in Increasing Doses: The Influence on Coronary Blood Flow and Oxidative Stress in Isolated Rat Hearts

“…In the cardiomyocyte-specific BK channel (CMBK) gene-targeted mice, the favorable effects on infarct formation were abolished and significantly reduced infarct size [18]. Some studies showed that tadalafil has anti-inflammatory properties as it led to the reduction of leukocyte infiltration in the kidneys after warm ischemia on a rat model [19]. Tadalafil properties of restoring NO signaling were used to manage metabolic syndrome in mice, which improved their lipid profile [1].…”

Current Concepts on the Reno-Protective Effects of Phosphodiesterase 5 Inhibitors in Acute Kidney Injury: Systematic Search and Review

“…The main characteristics and results of the human studies evaluating the potential reno-protective effects of PDE5Is are summarized in Table 1 [17,24,38,39]. The main characteristics and results of the animal studies on currently proposed AKI models evaluating the potential reno-protective effects of sildenafil, tadalafil, icariin, vardenafil, zaprinast-udenafil are summarized in Table 2 [23,30,, Table 3 [29,35,45,49,[62][63][64][65][66][67][68][69][70][71][72][73][74], Table 4 [18,75,76], Table 5 [45,77,78], and Table 6 [21,40,79,80], respectively. The main characteristics and results of the animal studies in the AKI-CKD transition spectrum (focusing on renal function and/or structure alterations for up to three months, not fulfilling the KDIGO definition for CKD [6]) evaluating the potential reno-protective effects of sildenafil, tadalafil, icariin, vardenafil, zaprinast-udenafil are summarized in Table A1 [109,110], respectively (Appendix B).…”

A Novel Mitophagy Enhancer Protects Cardiomyocytes against Hypoxia/Reoxygenation

“…b-carbolines are biologically active alkaloids, and these compounds have been reported to possess a wide range of biological effects, such as anti-inflammatory, antithrombotic activities, antivirus, anticancer and free radical scavenging activities [46]. Previous studies demonstrated the potential application of b-carboline derivatives in the treatment of cardiovascular diseases like hypertension [47], myocardial infarction [25], [48], cancer [49][50][51][52], and ischemia/reperfusion injury [53][54][55][56][57][58][59]. In addition, 4-hydroxy-2,2,6,6-tetramethyl-piperidine-N-oxyl (Tempol) has gained attention.…”