2017
DOI: 10.1590/s0102-865020170105
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Abstract: Purpose: To evaluate the expression of endothelial and inducible NOS in addition to the miRNA27b in the corpus cavernosum and peripheral blood of healthy rats, diabetic rats, alcoholic rats and rats with both pathologies. Methods: Forty eight Wistar rats were divided into four groups: control (C), alcoholic (A), diabetic (D) and alcoholic-diabetic (AD). Samples of the corpus cavernosum were prepared to study protein expressions of eNOS and iNOS by immunohistochemistry and expression of miRNA-27b in the corpus … Show more

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Cited by 6 publications
(3 citation statements)
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References 20 publications
(14 reference statements)
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“…However, according to current clinical results, at least 30% of ED patients do not respond to PDE5 inhibitors, in diabetic ED patients, the failed-treated patients were up to 40%-60% 3 . Meanwhile, the eNOS in the diabetic animal model did not significantly decrease in CC 50 , 51 . We here found that the ablation of MYPT1 expression led to reduced sensitivity to nitric oxide for penile smooth muscle relaxation.…”
Section: Discussionmentioning
confidence: 83%
“…However, according to current clinical results, at least 30% of ED patients do not respond to PDE5 inhibitors, in diabetic ED patients, the failed-treated patients were up to 40%-60% 3 . Meanwhile, the eNOS in the diabetic animal model did not significantly decrease in CC 50 , 51 . We here found that the ablation of MYPT1 expression led to reduced sensitivity to nitric oxide for penile smooth muscle relaxation.…”
Section: Discussionmentioning
confidence: 83%
“…However, according to current clinical results, at least 30% of ED patients do not respond to PDE5 inhibitors, in diabetic ED patients, the failed-treated patients were up to 40%-60% 5 . Meanwhile, the eNOS in the diabetic animal model did not significantly decrease in CC 43,44 . We here found that the ablation of MYPT1 expression led to reduced sensitivity to nitric oxide for penile smooth muscle relaxation.…”
Section: Discussionmentioning
confidence: 84%
“…13,14 Estudos promissores chamam a atenção para seu potencial uso como biomarcador, podendo ser úteis para o diagnóstico e tratamento de doenças. 15 Pesquisas prévias do grupo mostraram o possível envolvimento da expressão do miRNA 27 com a via óxido nítrico sintase endotelial (eNOS) e induzível (iNOS) nos corpos cavernosos 16 ; e a relação entre a expressão do miRNA-155 e miRNA-199 com apresentação dos receptores de endotelinas (ET) no modelo experimental de ratos submetidos ao alcoolismo, diabetes e sua associação. 17 Os miRNA 15b, 16,138, 221 e 222 apresentam conhecida expressão relacionada às células endotelias e demonstrada importância na fisiologia vascular, angiogênese e remodelação vascular.…”
Section: Nadph-nicotinamide Adenine Dinucleotide Phosphateunclassified