2017
DOI: 10.1590/s0102-865020170103
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Purpose: To assess the effectiveness of heparin, platelet-rich plasma (PRP), and silver nanoparticles on prevention of postoperative adhesion in animal models. Methods: Sixty males Albino Wistar rats aged 5 to 6 weeks were classified into five groups receiving none, heparin, PRP, silver nanoparticles, PRP plus silver nanoparticles intraperitoneally. After 2 weeks, the animals underwent laparotomy and the damaged site was assessed for peritoneal adhesions severity. Results: The mean severity scores were 2.5 ± 0… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
6
0

Year Published

2017
2017
2023
2023

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 12 publications
(6 citation statements)
references
References 26 publications
(24 reference statements)
0
6
0
Order By: Relevance
“…The PPA-preventive effect was equally observed with heparin sodium (HS) and EHA-m in both macroscopic and histopathologic examinations in the present study. Anticoagulants have already been investigated for PPA prevention in several experimental studies and found to be effective in adhesion prevention [7,15,20]. Although the use of heparin in early postoperative period is questionable, intra-peritoneal administration of heparin was showed to be a safe method for PPA prevention [15].…”
Section: Discussionmentioning
confidence: 99%
“…The PPA-preventive effect was equally observed with heparin sodium (HS) and EHA-m in both macroscopic and histopathologic examinations in the present study. Anticoagulants have already been investigated for PPA prevention in several experimental studies and found to be effective in adhesion prevention [7,15,20]. Although the use of heparin in early postoperative period is questionable, intra-peritoneal administration of heparin was showed to be a safe method for PPA prevention [15].…”
Section: Discussionmentioning
confidence: 99%
“…In the current literature, methods such as blockage of immunological factors and mode of actions (tumor necrotizing factor), administration of high dose botulinum toxin, pure olive oil, and platelet-rich plasma have been proven successful in preventing postoperative adhesions by promising studies [18][19][20][21].…”
Section: Discussionmentioning
confidence: 99%
“…According to their results platelet-rich plasma had the lower severity score, none of the rat was classified as 3 or 4 [29]. Despite all these efforts on molecular therapy and usage of medical products, we believe that different life stile would lead to better recovery of abdominal motility and lower complications due to abdominal adhesions.…”
Section: Surgical Techniquementioning
confidence: 94%