2017
DOI: 10.1590/s0102-865020170100000007
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Abstract: Purpose: To evaluate the preventive effect of ascorbic acid on sevoflurane-induced acute renal failure in an experimental rat model. Methods: Twenty-four adult male Wistar rats were randomly distributed into three groups. Subjects were allocated into 3 groups: Group I received sevoflurane only, whereas Groups II and III had moderate (150 mg/kg) and high (300 mg/kg) doses of AA in addition to sevoflurane, respectively. Rhabdomyolysis and myohemoglobinuric ARF was formed by intramuscular administration of glycer… Show more

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Cited by 4 publications
(3 citation statements)
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“…In kidney injuries, overexpression of NGAL could be related to an intensive oxidative stress mechanism. Some studies have demonstrated that HO-1 activity decreases NGAL levels (43,44).…”
Section: The Effects Of Ho-1 Treatment On Kidney Tissuesmentioning
confidence: 99%
“…In kidney injuries, overexpression of NGAL could be related to an intensive oxidative stress mechanism. Some studies have demonstrated that HO-1 activity decreases NGAL levels (43,44).…”
Section: The Effects Of Ho-1 Treatment On Kidney Tissuesmentioning
confidence: 99%
“…In a recent animal study, 24 adult male Wistar rats were randomly distributed into three groups: Group I received sevoflurane only, whereas Groups II and III additionally received moderate (150 mg/kg) and high (300 mg/kg) doses of ascorbic acid. The study found a dose-dependent reduction of acute tubular necrosis in the ascorbic acid group [29]. In patients with severe sepsis and septic shock treated with colistin according to a modified pharmacokinetics-pharmacodynamics (PK/PD)-based dosing strategy, Dalfino et al identified baseline renal impairment and older age as strong predictors of AKI occurrence.…”
Section: Renoprotective Effects Of Vitamin Cmentioning
confidence: 99%
“…(15) Vitamin C dapat mengurangi cedera akibat stres oksidatif di ginjal, dan mungkin juga memiliki efek pencegahan terhadap nefrotoksisitas. (16) Vitamin C atau vitamin E saja dan kombinasi keduanya mempertahankan kadar antioksidan ginjal dan mencegah kerusakan ginjal. Penurunan ekskresi protein urin dan peningkatan fungsi ginjal pada kelompok yang diberi vitamin antioksidan menunjukkan peran utama stres oksidatif dalam perkembangan disfungsi ginjal.…”
Section: ✱ ✱ ✱unclassified