2017
DOI: 10.1590/s0102-865020170100000003
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Abstract: Combination of local ischemic preconditioning (IPC) and topical hypothermia conferred no protection in renal I/R injury. Moreover, local IPC solely followed by warm ischemia impaired renal function more than warm ischemia alone.

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Cited by 6 publications
(4 citation statements)
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“…In addition, acute kidney injury developed in 43% of patients resuscitated after CA, and more than 75% of these episodes occurred within three days following CA ( 45 ). In animal models, acute kidney injury induced by I/R (i.e., ROSC following CA) was significantly attenuated by HT ( 43 , 46 , 47 ). For example, Tissier et al ( 47 ) reported significant attenuation of kidney lesions by HT in a rabbit model of CA, based on histopathology and electron microscopy, compared with the control group.…”
Section: Discussionmentioning
confidence: 99%
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“…In addition, acute kidney injury developed in 43% of patients resuscitated after CA, and more than 75% of these episodes occurred within three days following CA ( 45 ). In animal models, acute kidney injury induced by I/R (i.e., ROSC following CA) was significantly attenuated by HT ( 43 , 46 , 47 ). For example, Tissier et al ( 47 ) reported significant attenuation of kidney lesions by HT in a rabbit model of CA, based on histopathology and electron microscopy, compared with the control group.…”
Section: Discussionmentioning
confidence: 99%
“…In our present study, renal glomerular and tubular lesions and histopathological scores in Group III were significantly reduced following 4 h- and 6 h-HT one day following ROSC compared with Group II. Ribeiro et al ( 46 ) and Souza et al ( 50 ) reported that HT was effective in animal models of renal I/R injury. Islam et al ( 23 ) and Jawad et al ( 22 ) determined that HT reduced the severity of renal injury and increased the survival rate in an asphyxial CA model.…”
Section: Discussionmentioning
confidence: 99%
“…Despite several studies evaluating ischemic preconditioning, there are no studies combining RIPC and hypothermia to identify whether there is a synergistic protective effect when applying these two modalities for protection against the effects of prolonged IR on renal tissue. The association between local renal preconditioning and transoperative hypothermia was investigated by Ribeiro et al 25 , when LIPC was performed with and without low kidney temperatures. The results did not demonstrate the synergistic effects of LIPC concomitant with hypothermia in renal protection during IR.…”
Section: ■ Discussionmentioning
confidence: 99%
“…In contrast, urea concentrations were significantly lower in the MEL+TH+IR group than in the other groups (P<0.001), likely due to the synergistic protective effect of both interventions. The benefits of cold ischemia at 4°C include reduction of cellular metabolism 26,27 and in the production of xanthine oxidase 7 , whereas the benefits of MEL include the activation of antioxidant enzymes and the protection of oxidative phosphorylation. Thus, together, cold ischemia and MEL reduce creatinine and urea concentrations, both parameters of renal function.…”
mentioning
confidence: 99%